Stability and reliability of enhanced external-internal motion correlation via dynamic phase-shift corrections over 30-min timeframe for respiratory-gated radiotherapy Journal Article
| Authors: | Milewski, A.; Li, G. |
| Article Title: | Stability and reliability of enhanced external-internal motion correlation via dynamic phase-shift corrections over 30-min timeframe for respiratory-gated radiotherapy |
| Abstract: | To assess the stability of patient-specific phase shifts between external- and internal-respiratory motion waveforms, the reliability of enhanced external–internal correlation with phase-shift correction, and the feasibility of guiding respiratory-gated radiotherapy (RGRT) over 30 min. In this clinical feasibility investigation, external bellows and internal-navigator waveforms were simultaneously and prospectively acquired along with two four-dimensional magnetic resonance imaging (4DMRI) scans (6–15 m each) with 15–20 m intervals in 10 volunteers. A bellows was placed 5 cm inferior to the xiphoid to monitor abdominal motion, and an MR navigator was used to track the diaphragmatic motion. The mean phase-domain (MPD) method was applied, which combines three individual phase-calculating methods: phase-space oval fitting, principal component analysis, and analytic signal analysis, weighted by the reciprocal of their residual errors (RE) excluding outliers (RE >2σ). The time-domain cross-correlation (TCC) analysis was applied for comparison. Dynamic phase-shift correction was performed based on the phase shift detected on the fly within two 10 s moving datasets. Simulating bellows-triggered gating, the median and 95% confidence interval for the navigator's position at beam-on/beam-off and %harm (percentage of beam-on time outside the safety margin) were calculated. Averaged across all subjects, the mean phase shifts are found indistinguishable (p >.05) between scan 1 (55 ̊ ± 9 ̊) and scan 2 (59 ̊ ± 11 ̊). Using the MPD method the averaged correlation increases from 0.56 ± 0.22 to 0.85 ± 0.11 for scan 1 and from 0.47 ± 0.30 to 0.84 ± 0.08 for scan 2. The TCC correction results in similar results. After phase-shift correction, the number of cases that were suitable for amplitude gating (with <10%harm) increased from 2 to 17 out of 20 cases. A patient-specific, stable phase-shift between the external and internal motions was observed and corrected using the MPD and TCC methods, producing long-lasting enhanced motion correlation over 30m. Phase-shift correction offers a feasible strategy for improving the accuracy of tumor-motion prediction during RGRT. © The Author(s) 2022. |
| Keywords: | adult; clinical article; controlled study; cancer radiotherapy; nuclear magnetic resonance imaging; reproducibility; reproducibility of results; radiotherapy; prediction; correlation analysis; intermethod comparison; reliability; radiotherapy planning, computer-assisted; motion; respiration; principal component analysis; breathing; movement; movement (physiology); procedures; humans; human; male; female; article; radiotherapy planning system; respiratory gated radiotherapy; cross correlation; external–internal motion correlation; external–internal motion phase shift; four-dimensional mri; radiotherapy planning and delivery; tumor motion prediction |
| Journal Title: | Technology in Cancer Research & Treatment |
| Volume: | 21 |
| ISSN: | 1533-0346 |
| Publisher: | Sage Publications, Inc. |
| Date Published: | 2022-01-01 |
| Language: | English |
| DOI: | 10.1177/15330338221111592 |
| PUBMED: | 35880289 |
| PROVIDER: | scopus |
| PMCID: | PMC9340341 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2022 -- Source: Scopus |
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