Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy Journal Article


Authors: Grabenstetter, A.; Brogi, E.; Zhang, H.; Razavi, P.; Reis-Filho, J. S.; VanZee, K. J.; Norton, L.; Wen, H. Y.
Article Title: Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
Abstract: Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC). Recent studies have shown that the SB-AdCC variant has significantly worse prognosis than C-AdCC. Due to the rarity of SB-AdCC, no standard recommendations are available for its management. Data on the use and benefit of chemotherapy in patients with SB-AdCC are sparse and the response to neoadjuvant chemotherapy has not been reported. We present the clinical and pathologic findings of a patient with SB-AdCC treated with neoadjuvant chemotherapy who achieved a remarkable pathologic response. © 2022, The Author(s).
Journal Title: npj Breast Cancer
Volume: 8
ISSN: 2374-4677
Publisher: Nature Publishing Group  
Date Published: 2022-08-11
Start Page: 93
Language: English
DOI: 10.1038/s41523-022-00469-z
PROVIDER: scopus
PMCID: PMC9372162
PUBMED: 35953528
DOI/URL:
Notes: Article -- Export Date: 1 September 2022 -- Source: Scopus
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MSK Authors
  1. Larry Norton
    758 Norton
  2. Kimberly J Van Zee
    293 Van Zee
  3. Hannah Yong Wen
    301 Wen
  4. Edi Brogi
    515 Brogi
  5. Pedram Razavi
    172 Razavi
  6. Hong Zhang
    54 Zhang