Precision medicine in non-small cell lung cancer: Current applications and future directions Review


Authors: Yang, S. R.; Schultheis, A. M.; Yu, H.; Mandelker, D.; Ladanyi, M.; Büttner, R.
Review Title: Precision medicine in non-small cell lung cancer: Current applications and future directions
Abstract: Advances in biomarkers, targeted therapies, and immuno-oncology have transformed the clinical management of patients with advanced NSCLC. For oncogene-driven tumors, there are highly effective targeted therapies against EGFR, ALK, ROS1, BRAF, TRK, RET, and MET. In addition, investigational therapies for KRAS, NRG1, and HER2 have shown promising results and may become standard-of-care in the near future. In parallel, immune-checkpoint therapy has emerged as an indispensable treatment modality, especially for patients lacking actionable oncogenic drivers. While PD-L1 expression has shown modest predictive utility, biomarkers for immune-checkpoint inhibition in NSCLC have remained elusive and represent an area of active investigation. Given the growing importance of biomarkers, optimal utilization of small tissue biopsies and alternative genotyping methods using circulating cell-free DNA have become increasingly integrated into clinical practice. In this review, we will summarize the current landscape and emerging trends in precision medicine for patients with advanced NSCLC with a special focus on predictive biomarker testing. © 2020 Elsevier Ltd
Keywords: immunohistochemistry; oncoprotein; overall survival; single nucleotide polymorphism; genetics; mutation; proto-oncogene proteins; review; advanced cancer; drug efficacy; drug approval; cancer patient; outcome assessment; polymerase chain reaction; cancer immunotherapy; progression free survival; carcinoma, non-small-cell lung; lung neoplasms; cancer screening; protein tyrosine kinase; mutational analysis; tumor marker; cancer resistance; protein tyrosine kinase inhibitor; lung tumor; fluorescence in situ hybridization; protein-tyrosine kinases; trend study; lung biopsy; tissue fixation; cytodiagnosis; turnaround time; personalized medicine; non small cell lung cancer; molecularly targeted therapy; genotyping; fine needle aspiration biopsy; sanger sequencing; humans; human; precision medicine; pembrolizumab; osimertinib; liquid biopsy; biomarkers, tumor; tumor mutational burden; histological and molecular diagnostics; lung cancer diagnostics; resistance to egfr-tkis
Journal Title: Seminars in Cancer Biology
Volume: 84
ISSN: 1044-579X
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 2022-09-01
Start Page: 184
End Page: 198
Language: English
DOI: 10.1016/j.semcancer.2020.07.009
PUBMED: 32730814
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 1 August 2022 -- Source: Scopus
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MSK Authors
  1. Helena Alexandra Yu
    186 Yu
  2. Marc Ladanyi
    1190 Ladanyi
  3. Diana Lauren Mandelker
    108 Mandelker
  4. Soo Ryum Yang
    28 Yang