The solid variant of papillary thyroid carcinoma: A multi-institutional retrospective study Journal Article
| Authors: | Xu, B.; Viswanathan, K.; Zhang, L.; Edmund, L. N.; Ganly, O.; Tuttle, R. M.; Lubin, D.; Ghossein, R. A. |
| Article Title: | The solid variant of papillary thyroid carcinoma: A multi-institutional retrospective study |
| Abstract: | Aims: The definition of papillary thyroid carcinoma, solid variant (PTC-SV) varies from >50% to 100% of solid/trabecular/insular growth (STI). We aimed to identify prognostic factors and to establish an appropriate STI cutoff for PTC-SV in this multi-institutional study of 156 PTCs with STI. Results: Nodal metastases were seen in 18% and were associated with a higher percentage of papillary and STI. When substratified by infiltration/encapsulation status, the STI percentage did not impact the risk of nodal metastasis. pN1 stage was seen in 51% of infiltrative tumours and 1% of encapsulated lesions. Overall, PTC with STI had an excellent prognosis. The 10-year disease-free survival (DFS) was 87% in the entire cohort, 94% in encapsulated lesions, and 76% in infiltrative tumours. The STI percentage did not impact DFS. Fifty-four patients had noninvasive encapsulated lesions with 2–100% STI. None developed recurrence. Encapsulated lesions were enriched with RAS mutations (54%), whereas infiltrative lesions lacked RAS mutations (4%). The BRAF V600E mutation was an infrequent event, being seen in 11% of the entire cohort. Conclusion: In PTC with STI, the determining factor for nodal metastasis and DFS is the encapsulation/infiltration status rather than the STI percentage. Encapsulated noninvasive tumours with STI follow an indolent course with a very low risk of nodal metastasis and recurrence. Overall, PTC with STI has an excellent prognosis, with a 10-year disease-specific survival (DSS) and DFS of 96% and 87%, respectively. Therefore, the classification of SV-PTC as an aggressive PTC subtype may be reconsidered. © 2022 John Wiley & Sons Ltd. |
| Keywords: | retrospective studies; genetics; mutation; clinical trial; pathology; retrospective study; multicenter study; thyroid neoplasms; b raf kinase; thyroid tumor; braf; ras; proto-oncogene proteins b-raf; papillary thyroid carcinoma; humans; human; solid variant; noninvasive follicular thyroid neoplasm with papillary-like nuclear features (niftp); thyroid cancer, papillary |
| Journal Title: | Histopathology |
| Volume: | 81 |
| Issue: | 2 |
| ISSN: | 0309-0167 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2022-08-01 |
| Start Page: | 171 |
| End Page: | 182 |
| Language: | English |
| DOI: | 10.1111/his.14668 |
| PUBMED: | 35474588 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2022 -- Source: Scopus |
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