Transarterial chemoembolization with doxorubicin eluting beads for extra-abdominal desmoid tumors: Initial experience Journal Article
| Authors: | Kim, D.; Keohan, M. L.; Gounder, M. M.; Crago, A. M.; Erinjeri, J. P. |
| Article Title: | Transarterial chemoembolization with doxorubicin eluting beads for extra-abdominal desmoid tumors: Initial experience |
| Abstract: | Purpose: To evaluate the feasibility, efficacy, and safety of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) as an alternative local treatment for extra-abdominal desmoid tumors (DTs). Methods: Eleven adult female patients (mean age = 40.1 years) with symptomatic, progressively enlarging extra-abdominal DTs were determined ineligible for cryoablation after failing observation or systemic therapy and treated with a single session doxorubicin DEB-TACE. Six rectus sheath, one chest wall, three axilla, and one upper extremity DTs were included. The median follow-up was 155.0 ± 52.3 days. Treatment response was assessed by MRIs and maximum visual analog scale (VAS). Results: All procedures were technically successful without immediate complications. The average size of treated DT was 161.8 ml (range: 28.3–420.0 ml). The mean doxorubicin dose was 13.3 mg/m2. All patients experienced skin changes which improved over time without treatments. No higher-grade adverse events were observed. Initial one-month follow-up MRI demonstrated partial to near-complete tumor necrosis, ranging from 1.4 to 97.6% (mean: 36.4%). Additional follow-up revealed a further reduction of overall tumor volume (mean: − 38.1%, p < 0.0001) and maximum VAS (mean: − 2.6, p = 0.0026) in 10 out of 11 patients (90.9%). After the first month, the residual tumors exhibited continued volume reduction in 10 out of 11 patients (mean: − 16.5%, p = 0.0230). There was also a significant decrease of T2 signal intensity within residual tumor on the latest follow-up (mean: − 29.6%, p = 0.0217), suggesting a reduction in tumor cellularity. Conclusion: DEB-TACE may be a safe and effective local treatment alternative in DT patients. © 2022, Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). |
| Keywords: | doxorubicin; desmoid tumor; locoregional therapy; image-guided therapy; drug-eluting bead transarterial chemoembolization (deb-tace) |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 45 |
| Issue: | 8 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2022-08-01 |
| Start Page: | 1141 |
| End Page: | 1151 |
| Language: | English |
| DOI: | 10.1007/s00270-022-03149-4 |
| PUBMED: | 35441242 |
| PROVIDER: | scopus |
| PMCID: | PMC9400546 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2022 -- Source: Scopus |
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