Matched preliminary analysis of patient-reported outcomes following autologous and implant-based breast reconstruction Journal Article
| Authors: | Nelson, J. A.; Shamsunder, M. G.; Myers, P. L.; Polanco, T. O.; Coriddi, M. R.; McCarthy, C. M.; Matros, E.; Dayan, J. H.; Disa, J. J.; Mehrara, B. J.; Pusic, A. L.; Allen, R. J. Jr |
| Article Title: | Matched preliminary analysis of patient-reported outcomes following autologous and implant-based breast reconstruction |
| Abstract: | Background: Comparisons of autologous breast reconstruction (ABR) and implant-based breast reconstruction (IBR) involve unavoidable confounders, which are often adjusted for in post hoc regression analyses. This study compared patient-reported outcomes between ABR patients and IBR patients by using propensity score matching to control for confounding variables upfront. Methods: Propensity score matching analysis (2:1 nearest-neighbor matching with replacement) was performed for patients who underwent ABR or IBR without radiotherapy. Matched covariates included age, body mass index, history of psychiatric diagnosis, race–ethnicity, smoking status, and laterality of reconstruction. Outcomes of interest were BREAST-Q questionnaire scores for breast satisfaction and well-being. Results: Of the 2334 patients identified, 427 were included in the final analysis: 159 who underwent ABR and 268 who underwent IBR. The ABR group matched the IBR group in the selected characteristics. ABR patients did not differ significantly from IBR patients in breast satisfaction or well-being at either 1 or 2 years after reconstructive surgery. Conclusions: This preliminary analysis of immediate breast reconstruction patients not requiring radiation therapy with similar propensities for ABR or IBR suggests comparable levels of breast satisfaction and well-being within 2 years after reconstructive surgery. Further research is needed with larger sample sizes, statistical power, and follow-up to better understand patient reported outcomes in this population, as the current findings differ from studies where patients were not matched on baseline characteristics. © 2022, Society of Surgical Oncology. |
| Keywords: | adult; cancer chemotherapy; controlled study; patient satisfaction; major clinical study; hypertension; outcome assessment; antineoplastic agent; breast cancer; mastectomy; breast neoplasms; breast reconstruction; mammaplasty; questionnaire; cancer center; body mass; breast tumor; diabetes mellitus; patient reported outcome measures; deep inferior epigastric perforator flap; transverse rectus abdominis musculocutaneous flap; superficial inferior epigastric artery flap; nipple-sparing mastectomy; transplantation, autologous; adverse event; autotransplantation; confounding variable; patient-reported outcome; propensity score; reconstructive surgery; breast-q; humans; human; female; article; surveys and questionnaires; physical well-being; minimal clinically important difference; people by smoking status; social well-being; american society of anaesthesiologists score; sexual well-being |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 29 |
| Issue: | 8 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2022-08-01 |
| Start Page: | 5266 |
| End Page: | 5275 |
| Language: | English |
| DOI: | 10.1245/s10434-022-11504-5 |
| PUBMED: | 35366702 |
| PROVIDER: | scopus |
| PMCID: | PMC9253052 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2022 -- Source: Scopus |
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