Neoadjuvant and adjuvant therapy for local excision of rectal cancer Review

  


Authors: Feferman, Y.; Garcia-Aguilar, J.
Review Title: Neoadjuvant and adjuvant therapy for local excision of rectal cancer
Abstract: Local excision (LE) for early-stage rectal cancer is an attractive option compared to total mesorectal excision (TME), as it avoids many of the significant comorbidities and adverse functional outcomes associated with TME. However, LE for tumors with high-risk histopathologic features can lead to unacceptably high rates of local and distant recurrence. Neoadjuvant or adjuvant chemoradiotherapy can mitigate those risks in certain clinical settings and may expand the number of patients who can be safely treated with an organ-preserving approach. In this chapter, we will explore the available date supporting the use of neoadjuvant and adjuvant chemoradiation (CRT) for the treatment of high-risk early-stage rectal cancer and will discuss future studies that aim to answer some of the ongoing clinical questions related to this practice. © 2022
Keywords: organ preservation; rectal cancer; total mesorectal excision; local excision; neoadjuvant chemoradiotherapy
Journal Title: Seminars in Colon and Rectal Surgery
Volume: 33
Issue: 3
ISSN: 1043-1489
Publisher: Elsevier Inc.  
Date Published: 2022-09-01
Start Page: 100900
Language: English
DOI: 10.1016/j.scrs.2022.100900
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134354574&doi=10.1016%2fj.scrs.2022.100900&partnerID=40&md5=453d265c0a6d54cbfed622863982e7d5
Notes: Export Date: 1 August 2022 -- Source: Scopus
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MSK Authors
  1. Julio Garcia Aguilar
    345 Garcia Aguilar
  2. Yael Feferman
    4 Feferman
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