Obesity and breast cancer risk: The oncogenic implications of metabolic dysregulation Journal Article


Authors: Naaman, S. C.; Shen, S.; Zeytinoglu, M.; Iyengar, N. M.
Article Title: Obesity and breast cancer risk: The oncogenic implications of metabolic dysregulation
Abstract: CONTEXT: Breast cancer is increasing in prevalence in parallel with rising rates of obesity worldwide. Obesity is recognized as a leading modifiable risk factor for the development of breast cancer; however, this association varies considerably by clinicopathologic features, and the underlying mechanisms are complex. EVIDENCE ACQUISITION: Pubmed literature search using combinations of "obesity," "breast cancer risk," "diet," "exercise," "weight gain," "weight loss," "adipose tissue inflammation," "crown-like structure," "immune markers," "metformin," "gliflozins," "SGLT-2i," "GLP1-RA," and related terms. EVIDENCE SYNTHESIS: Elevated body mass index and weight gain are associated with increased risk of postmenopausal, hormone receptor-positive breast cancer. Emerging evidence suggests that adverse measures of body composition in individuals of any weight can also confer increased breast cancer risk. Mechanistically, various factors including altered adipokine balance, dysfunctional adipose tissue, dysregulated insulin signaling, and chronic inflammation contribute to tumorigenesis. Weight loss and more specifically fat mass loss through lifestyle and pharmacologic interventions improve serum metabolic and inflammatory markers, sex hormone levels, and measures of breast density, suggesting a link to decreased breast cancer risk. CONCLUSION: Incorporating markers of metabolic health and body composition measures with body mass index can capture breast cancer risk more comprehensively. Further studies of interventions targeting body fat levels are needed to curb the growing prevalence of obesity-related cancer. © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Keywords: metabolism; breast cancer; inflammation; risk factors; weight loss; obesity; breast neoplasms; risk factor; carcinogenesis; body mass; body mass index; breast tumor; metabolic; weight gain; complication; body weight loss; humans; human; female; body weight gain
Journal Title: Journal of Clinical Endocrinology and Metabolism
Volume: 107
Issue: 8
ISSN: 0021-972X
Publisher: Oxford University Press  
Date Published: 2022-08-01
Start Page: 2154
End Page: 2166
Language: English
DOI: 10.1210/clinem/dgac241
PUBMED: 35453151
PROVIDER: scopus
PMCID: PMC9282365
DOI/URL:
Notes: Article -- Export Date: 1 August 2022 -- Source: Scopus
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  1. Neil Mukund Iyengar
    150 Iyengar
  2. Sherry Shen
    22 Shen