Multifocal and pathologically-confirmed brain metastasis complete response to trastuzumab deruxtecan Journal Article

   

Authors:	Moss, N. S.; Tosi, U.; Santomasso, B. D.; Beal, K.; Modi, S.
Article Title:	Multifocal and pathologically-confirmed brain metastasis complete response to trastuzumab deruxtecan
Abstract:	Antibody-drug conjugates have transformed the treatment of HER2+ breast and other cancers. Unfortunately, the CNS remains a sanctuary site for many such patients in part due to poor macromolecule penetration across the blood-brain tumor barrier. Trastuzumab deruxtecan (T-DXd), a high-payload antibody-drug conjugate, was recently found to improve progression-free survival in HER2+ breast cancer patients versus prior-generation trastuzumab emtansine, prompting us to evaluate CNS activity in a woman with brain-only metastatic disease. T-DXd achieved complete response despite heavy pretreatment. Three persistent, previously-irradiated lesions were biopsy-proven to represent treatment effect. Subsequent recurrence occurred upon treatment holiday; partial response was observed with rechallenge. This case suggests T-DXd is active in HER2+ breast cancer brain metastases and supports further prospective evaluation. © 2022 The Authors.
Keywords:	adult; clinical article; human tissue; prednisone; histopathology; cancer recurrence; case report; bevacizumab; doxorubicin; drug withdrawal; capecitabine; paclitaxel; adjuvant therapy; cancer radiotherapy; brain tumor; metastasis; multiple cycle treatment; cyclophosphamide; steroid; breast neoplasms; pneumonia; goserelin; breast tumor; drug response; brain metastasis; tamoxifen; corticosteroid; trastuzumab; anastrozole; brain biopsy; radiation necrosis; brain edema; neratinib; pertuzumab; lumpectomy; brain neoplasm; toxic hepatitis; human epidermal growth factor receptor 2 positive breast cancer; human; female; article; trastuzumab deruxtecan; tucatinib
Journal Title:	CNS Oncology
Volume:	11
Issue:	3
ISSN:	2045-0907
Publisher:	Future Medicine
Date Published:	2022-09-01
Start Page:	CNS90
Language:	English
DOI:	10.2217/cns-2022-0010
PUBMED:	35674041
PROVIDER:	scopus
PMCID:	PMC9280405
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134256845&doi=10.2217%2fcns-2022-0010&partnerID=40&md5=c1f99678901ee5e31333c7b82e8c3708
Notes:	Article -- Export Date: 1 August 2022 -- Source: Scopus

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