Bystander effect of antibody–drug conjugates: Fact or fiction? Review
| Authors: | Giugliano, F.; Corti, C.; Tarantino, P.; Michelini, F.; Curigliano, G. |
| Review Title: | Bystander effect of antibody–drug conjugates: Fact or fiction? |
| Abstract: | Purpose of review: Summarizing the current preclinical and clinical evidence about bystander effect of antibody–drug conjugates (ADCs) in solid tumors. Recent findings: One of the main challenges of treating solid tumors with ADCs is the heterogeneous expression of the target antigen (Ag), which however may be overcome by the so-called bystander killing effect. This unique, but still debated, feature of certain ADCs is represented by the unintentional payload diffusion from Ag-positive tumor cells to adjacent Ag-negative tumor cells. Some pharmacological characteristics, such as a hydrophobic payload or a cleavable linker, seem to play a major role in this effect. Summary: Abundant preclinical evidence of the bystander effect has emerged, and the clinical activity of ADCs in tumors with a heterogeneous Ag expression suggests the relevance of this feature. Additional studies are required to investigate if the bystander effect is necessary for achieving a solid activity with ADCs. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | antineoplastic agents; antineoplastic agent; neoplasm; neoplasms; bystander effect; antibody conjugate; immunoconjugates; trastuzumab emtansine; humans; human; sacituzumab govitecan; trastuzumab deruxtecan; antibody–drug conjugates; bystander effect (cell) |
| Journal Title: | Current Oncology Reports |
| Volume: | 24 |
| Issue: | 7 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2022-07-01 |
| Start Page: | 809 |
| End Page: | 817 |
| Language: | English |
| DOI: | 10.1007/s11912-022-01266-4 |
| PUBMED: | 35305211 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2022 -- Source: Scopus |
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