An ascendant challenge: Central nervous system metastases in ALK+ lung cancers Editorial

   


Authors: Murciano-Goroff, Y. R.; Harada, G.; Drilon, A.
Title: An ascendant challenge: Central nervous system metastases in ALK+ lung cancers
Abstract: Central nervous system (CNS) metastases constitute a challenge for the design of anaplastic lymphoma kinase (ALK) fusion–positive lung cancer trials. The ASCEND-7 study of ceritinib demonstrates the feasibility of broadening CNS eligibility criteria to include symptomatic brain and leptomeningeal disease and highlights design features that contemporary trials will need to incorporate. © 2022 American Association for Cancer Research
Keywords: protein kinase inhibitor; carcinoma, non-small-cell lung; lung neoplasms; pathology; protein tyrosine kinase; pyrimidines; central nervous system tumor; central nervous system; central nervous system neoplasms; protein kinase inhibitors; lung tumor; brain; receptor protein-tyrosine kinases; pyrimidine derivative; sulfones; non small cell lung cancer; anaplastic lymphoma kinase; humans; human; ceritinib; sulfone
Journal Title: Clinical Cancer Research
Volume: 28
Issue: 12
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2022-06-15
Start Page: 2477
End Page: 2479
Language: English
DOI: 10.1158/1078-0432.Ccr-22-0341
PUBMED: 35394532
PROVIDER: scopus
PMCID: PMC9197849
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131903737&doi=10.1158%2f1078-0432.CCR-22-0341&partnerID=40&md5=36ed2e7e27230037a8a7dd0e69a30ce0
Notes: Article -- Export Date: 1 July 2022 -- Source: Scopus
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MSK Authors
  1. Alexander Edward Drilon
    632 Drilon
  2. Yonina Robbie Murciano-Goroff
    65 Murciano-Goroff
  3. Guilherme Harada
    28 Harada
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