Stem cells at odds with telomere maintenance and protection Review
| Authors: | Penev, A.; Markiewicz-Potoczny, M.; Sfeir, A.; Lazzerini Denchi, E. |
| Review Title: | Stem cells at odds with telomere maintenance and protection |
| Abstract: | Telomeres are distinctive structures that protect the ends of linear chromosomes and ensure genome stability. They are composed of long tracks of repetitive and G-rich DNA that is bound by shelterin, a dedicated six-subunit protein complex. In somatic cells, shelterin protects telomeres from the DNA damage response and regulates telomere length. Telomere repeats are replenished by telomerase, a specialized ribonucleoprotein composed of telomerase reverse transcriptase and an integral RNA component. Telomere protection and telomerase regulation have been primarily studied in somatic cells. However, recent evidence points out striking differences in the context of embryonic stem cells (ESCs). In this review, we discuss insights into telomere protection in ESCs versus somatic cells and summarize findings on telomerase regulation as a function of pluripotency. © 2021 |
| Keywords: | genetics; review; nonhuman; mouse; telomere; metabolism; somatic cell; embryonic stem cell; protein assembly; telomerase; stem cell; telomeric repeat binding factor 2; rna; gene expression regulation; chemistry; dna; enzyme regulation; guanine; genomic instability; alternative rna splicing; telomerase reverse transcriptase; dna damage response; embryonic stem cells; pluripotent stem cell; telomeric repeat binding factor 1; rap1 protein; splicing; shelterin; ribonucleoprotein; telomere length; telomere homeostasis; humans; human; shelterin complex |
| Journal Title: | Trends in Cell Biology |
| Volume: | 32 |
| Issue: | 6 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-06-01 |
| Start Page: | 527 |
| End Page: | 536 |
| Language: | English |
| DOI: | 10.1016/j.tcb.2021.12.007 |
| PUBMED: | 35063336 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 June 2022 -- Source: Scopus |
