Challenges to randomized trials in adult and congenital cardiac and thoracic surgery Review
| Authors: | Gaudino, M.; Chikwe, J.; Bagiella, E.; Fremes, S.; Jones, D. R.; Meyers, B.; Newburger, J. W.; Ohye, R. G.; Sassalos, P.; Wigle, D.; Di Franco, A. |
| Review Title: | Challenges to randomized trials in adult and congenital cardiac and thoracic surgery |
| Abstract: | Randomized trials in surgery face additional challenges compared with those in medicine. Some of the challenges are intrinsic to the nature of the field (eg, issues with blinding, learning curve and surgeons’ experience, and difficulties in defining the appropriate timing for comparative trials). Other issues are related to the surgical culture, the attitude of surgeons toward randomized trials, and the lack of support by professional and national bodies. In this review, a group of investigators with experience in trials in congenital and adult cardiac and thoracic surgery discusses the key issues with surgical trials and suggests potential solutions. © 2022 The Society of Thoracic Surgeons |
| Keywords: | adult; review; randomized controlled trials as topic; surgeon; thorax surgery; heart; thoracic surgical procedures; randomized controlled trial (topic); surgeons; thoracic surgery; learning curve; humans; human |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 113 |
| Issue: | 5 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2022-05-01 |
| Start Page: | 1409 |
| End Page: | 1418 |
| Language: | English |
| DOI: | 10.1016/j.athoracsur.2020.11.042 |
| PUBMED: | 33412133 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 June 2022 -- Source: Scopus |
