Claudin-18 as a promising surrogate marker for endocervical gastric-type carcinoma Journal Article
| Authors: | Kiyokawa, T.; Hoang, L.; Pesci, A.; Alvarado-Cabrero, I.; Oliva, E.; Park, K. J.; Soslow, R. A.; Stolnicu, S. |
| Article Title: | Claudin-18 as a promising surrogate marker for endocervical gastric-type carcinoma |
| Abstract: | HIK1083 and trefoil factor 2 (TFF2) are known to be expressed in gastric-type carcinoma (GAS), but they do not reliably mark all GASs, and focal expression can be missed in biopsy specimens. We aimed to investigate whether claudin-18 and alpha-methylacyl-CoA racemase (AMACR) could be surrogate markers to separate GAS from other types of endocervical adenocarcinoma (ECA) and to compare their usefulness with that of HIK1083 and TFF2. Claudin-18 and AMACR immunohistochemistry was performed, and the results were compared with that of TFF2 and HIK1083, using whole sections of 75 ECAs (22 GASs and 53 non-GASs) and 179 ECAs with tissue microarrays (TMAs). TMAs were built to simulate the assessment of immunohistochemical stains in small biopsies. Any membranous (claudin-18) or cytoplasmic/membranous (AMACR, TFF2, HIK1083) staining of >5% of tumor cells was considered positive. Of 75 ECAs with whole sections, claudin-18 was significantly more frequently expressed in GASs (21/22) compared with non-GASs (8/53) (P<0.01). In ECAs with TMAs, claudin-18 expression was significantly frequent in GASs (15/23, 65.2%) than in non-GASs (3/152, 2.0%; all usual-type) (P<0.01). All claudin-18-positive GASs showed intense staining except 1 case. Claudin-18 shared the same degree of sensitivity and specificity with HIK1083 and TFF2. Three clear cell carcinomas were positive for claudin-18, but none showed intense staining. AMACR was expressed in a subset of ECAs and showed no impact in distinguishing between GAS and other ECAs. Our results suggest that claudin-18 is a promising surrogate marker to separate GAS from other types of ECA, including clear cell carcinoma. © 2022 Lippincott Williams and Wilkins. All rights reserved. |
| Keywords: | adenocarcinoma; differential diagnosis; pathology; tumor marker; carcinoma; uterine cervical neoplasms; stomach neoplasms; uterine cervix tumor; stomach tumor; isomerase; racemases and epimerases; claudin; humans; human; female; endocervical adenocarcinoma; biomarkers, tumor; immunohistochemical marker; gastric type; claudins |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 46 |
| Issue: | 5 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2022-05-01 |
| Start Page: | 628 |
| End Page: | 636 |
| Language: | English |
| DOI: | 10.1097/pas.0000000000001847 |
| PUBMED: | 34864774 |
| PROVIDER: | scopus |
| PMCID: | PMC9018468 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2022 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work