PCIG: A web-based application to explore immune-genomics interactions across cancer types Journal Article
| Authors: | Pedrola, A.; Franch-Expósito, S.; Lahoz, S.; Esteban-Fabró, R.; Dienstmann, R.; Bassaganyas, L.; Camps, J. |
| Article Title: | PCIG: A web-based application to explore immune-genomics interactions across cancer types |
| Abstract: | Motivation: Genomic alterations can modulate the tumor immunophenotype depending on their nature and tissue of origin. Although this immune-genomic interaction may shape disease progression and response to immunotherapy, the factors governing such dynamics and the influence of each tissue-specific context remain poorly understood. Results: Here, we have developed the PanCancer ImmunoGenomics (PCIG) tool, a web-based resource that provides researchers with the opportunity to mine immunome-genome relationships across several cancer types using data from the Pan-Cancer Analysis of Whole-Genomes (PCAWG) study, which comprises >2,600 samples spanning across 20 different cancer primary sites. PCIG yields an integrative analysis of the crosstalk between somatic genomic alterations and different immune features, thus helping to understand immune response-related processes. © 2022 The Author(s) 2022. Published by Oxford University Press. |
| Journal Title: | Bioinformatics |
| Volume: | 38 |
| Issue: | 8 |
| ISSN: | 1367-4803 |
| Publisher: | Oxford University Press |
| Date Published: | 2022-04-15 |
| Start Page: | 2374 |
| End Page: | 2376 |
| Language: | English |
| DOI: | 10.1093/bioinformatics/btac111 |
| PROVIDER: | scopus |
| PMCID: | PMC9004641 |
| PUBMED: | 35179562 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2022 -- Source: Scopus |
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