Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor Journal Article

   

Authors:	Huang, J.; Zhong, Y.; Makohon-Moore, A. P.; White, T.; Jasin, M.; Norell, M. A.; Wheeler, W. C.; Iacobuzio-Donahue, C. A.
Article Title:	Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor
Abstract:	We performed a comparative analysis of human and 12 non-human primates to identify sequence variations in known cancer genes. We identified 395 human-specific fixed non-silent substitutions that emerged during evolution of human. Using bioinformatics analyses for functional consequences, we identified a number of substitutions that are predicted to alter protein function; one of these mutations is located at the most evolutionarily conserved domain of human BRCA2. © 2022 The Author(s)
Keywords:	genetics; mutation; proteins; animal; metabolism; animals; protein; brca2 protein; evolution, molecular; molecular evolution; primate; fertility; brca2; primates; pan troglodytes; chimpanzee; rad51; human evolution; brca2 protein, human; cancer; humans; human; cp: cancer; chlca; driver gene; dss1
Journal Title:	Cell Reports
Volume:	39
Issue:	5
ISSN:	2211-1247
Publisher:	Cell Press
Date Published:	2022-05-03
Start Page:	110771
Language:	English
DOI:	10.1016/j.celrep.2022.110771
PUBMED:	35508134
PROVIDER:	scopus
PMCID:	PMC11740715
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129347419&doi=10.1016%2fj.celrep.2022.110771&partnerID=40&md5=221163a289cd212428a690493681c5d0
Notes:	Article -- Export Date: 1 June 2022 -- Source: Scopus

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