Implementation strategies to increase clinical trial enrollment in a community-academic partnership and impact on Hispanic representation: An interrupted time series analysis Journal Article
| Authors: | Ledesma Vicioso, N.; Lin, D.; Gomez, D. R.; Yang, J. T.; Lee, N. Y.; Rimner, A.; Yamada, Y.; Zelefsky, M. J.; Kalman, N. S.; Rutter, C. E.; Kotecha, R. R.; Mehta, M. P.; Panoff, J. E.; Chuong, M. D.; Salner, A. L.; Ostroff, J. S.; Diamond, L. C.; Mathis, N. J.; Cahlon, O.; Pfister, D. G.; Zhang, Z.; Chino, F.; Tsai, J.; Gillespie, E. F. |
| Article Title: | Implementation strategies to increase clinical trial enrollment in a community-academic partnership and impact on Hispanic representation: An interrupted time series analysis |
| Abstract: | PURPOSE: Community-academic partnerships have the potential to improve access to clinical trials for under-represented minority patients who more often receive cancer treatment in community settings. In 2017, the Memorial Sloan Kettering (MSK) Cancer Center began opening investigator-initiated clinical trials in radiation oncology in targeted community-based partner sites with a high potential to improve diverse population accrual. This study evaluates the effectiveness of a set of implementation strategies for increasing overall community-based enrollment and the resulting proportional enrollment of Hispanic patients on trials on the basis of availability in community-based partner sites. METHODS: An interrupted time series analysis evaluating implementation strategies was conducted from April 2018 to September 2021. Descriptive analysis ofHispanic enrollment on investigator-initiated randomized therapeutic radiation trials open at community-based sites was compared with those open only at themain academic center. RESULTS: Overall, 84 patients were enrolled in clinical trials in the MSK Alliance, of which 48 (56%) identified as Hispanic. The quarterly patient enrollment pre- vs postimplementation increased from 1.39 (95% CI, -3.67 to 6.46) to 9.42 (95% CI, 2.05 to 16.78; P5 .017). In the investigator-initiated randomized therapeutic radiation trials open in the MSK Alliance, Hispanic representation was 11.5% and 35.9% in twometastatic trials and 14.2% in a proton versus photon trial. Inmatched trials open only at the main academic center, Hispanic representation was 5.6%, 6.0%, and 4.0%, respectively. CONCLUSION: A combination of practice-level and physician-level strategies implemented at community-based partner sites was associated with increased clinical trial enrollment, which translated to improved Hispanic representation. This supports the role Q:2 of strategic community-academic partnerships in addressing disparities in clinical trial enrollment. |
| Keywords: | physicians; physician; epidemiology; personnel; research personnel; humans; human; hispanic or latino; interrupted time series analysis |
| Journal Title: | JCO Oncology Practice |
| Volume: | 18 |
| Issue: | 5 |
| ISSN: | 2688-1527 |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2022-05-01 |
| Start Page: | e780 |
| End Page: | e785 |
| Language: | English |
| DOI: | 10.1200/op.22.00037 |
| PUBMED: | 35544650 |
| PROVIDER: | scopus |
| PMCID: | PMC10166438 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2022 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work