Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging Journal Article
| Authors: | Sonar, S. A.; Uhrlaub, J. L.; Coplen, C. P.; Sempowski, G. D.; Dudakov, J. A.; van den Brink, M. R. M.; LaFleur, B. J.; Jergović, M.; Nikolich-Žugich, J. |
| Article Title: | Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging |
| Abstract: | SignificanceOlder adults are more vulnerable to infection and less capable of vigorously responding to vaccination. The contribution of peripheral T cell maintenance defects to these processes is incompletely understood. Here, we provide evidence that lymph nodes (LNs), which are critical for naive T (TN) cell maintenance and initiation of new immune responses, age asynchronously. Skin-draining LNs undergo early (6 to 9 mo) and deeper LN and spleen late-life (18 mo) atrophy, characterized by reduced ability to maintain TN cells, structural and numerical loss of LN stromal cell microenvironments, and reduced immunity to cutaneous vaccination. These results highlight the critical role of age-related LN atrophy in functional immunity and immune homeostasis. |
| Keywords: | lymph nodes; t cells; mouse; animal; animals; mice; atrophy; pathology; mice, inbred c57bl; c57bl mouse; skin; lymph node; aging; homeostasis; secondary lymphoid organs |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 119 |
| Issue: | 17 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2022-04-26 |
| Start Page: | e2121028119 |
| Language: | English |
| DOI: | 10.1073/pnas.2121028119 |
| PUBMED: | 35439062 |
| PROVIDER: | scopus |
| PMCID: | PMC9169949 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2022 -- Source: Scopus |
