Romiplostim for chemotherapy-induced thrombocytopenia: Efficacy and safety of extended use Journal Article


Authors: Wilkins, C. R.; Ortiz, J.; Gilbert, L. J.; Yin, S.; Mones, J. V.; Parameswaran, R.; Mantha, S.; Soff, G. A.
Article Title: Romiplostim for chemotherapy-induced thrombocytopenia: Efficacy and safety of extended use
Abstract: Background: Chemotherapy-induced thrombocytopenia (CIT) is common during treatment with antineoplastic therapies and may adversely impact chemotherapy dose intensity. There is no approved therapy for CIT. In our recent phase II randomized study, romiplostim led to correction of platelet counts in 85% of treated patients and allowed resumption of chemotherapy, with low rates of recurrent CIT in the first two cycles or 8 weeks of chemotherapy. However, there is a lack of long-term data on the efficacy and safety of romiplostim in CIT. Objectives: To analyze efficacy and safety of romiplostim in the patients in the phase 2 study, who received romiplostim for ≥1 year. Patients/Methods: Twenty-one patients remained on romiplostim for ≥1 year. We analyzed the effect of romiplostim on platelet counts, absolute neutrophil counts, and hemoglobin, as well as impact on ongoing chemotherapy. We also tracked venous or arterial thrombotic events. Results: During the study period, romiplostim was effective in preventing reduction of chemotherapy dose intensity due to CIT. Fourteen of the 20 (70%) analyzable patients experienced no episode of CIT, 4 subjects experienced a single chemotherapy dose delay due CIT, and 2 patients required a chemotherapy dose reduction. Platelet counts were preserved throughout the duration of the extension analysis. One patient experienced a proximal deep vein thrombosis, and one patient experienced multiple tumor-related ischemic events. Conclusions: Long-term use of romiplostim for treatment of CIT was effective and safe, with no evidence of resistance or increased risk of thrombosis. © 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH).
Keywords: chemotherapy; thrombocytopenia; romiplostim; thrombopoietin; cancer
Journal Title: Research and Practice in Thrombosis and Haemostasis
Volume: 6
Issue: 3
ISSN: 2475-0379
Publisher: Wiley Blackwell  
Date Published: 2022-03-01
Start Page: e12701
Language: English
DOI: 10.1002/rth2.12701
PROVIDER: scopus
PMCID: PMC9087952
PUBMED: 35582038
DOI/URL:
Notes: Article -- Export Date: 1 June 2022 -- Source: Scopus
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  1. Simon H Mantha
    71 Mantha
  2. Cy Rance Wilkins
    18 Wilkins
  3. Jodi Victoria Mones
    20 Mones
  4. Jocelyn A. Ortiz
    2 Ortiz