Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic Review

   


Authors: Bewersdorf, J. P.; Abdel-Wahab, O.
Review Title: Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic
Abstract: Despite FDA approval of nine new drugs for patients with acute myeloid leukemia (AML) in the United States over the last 4 years, AML remains a major area of unmet medical need among hematologic malignancies. In this review, we discuss the development of promising newmolecular targeted approaches for AML, including menin inhibition, novel IDH1/2 inhibitors, and preclinical means to target TET2, ASXL1, and RNA splicing factor mutations. In addition, we review progress in immune targeting of AML through anti-CD47, anti-SIRPα, and anti- TIM-3 antibodies; bispecific and trispecific antibodies; and new cellular therapies in development for AML. © 2022 Bewersdorf and Abdel-Wahab.
Keywords: mutation; leukemia, myeloid, acute; rna splicing; myelodysplastic syndromes; idh1; tet2; asxl1; acute myeloid leukemia; idh2; humans; human; menin
Journal Title: Genes and Development
Volume: 34
Issue: 5-6
ISSN: 0890-9369
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2022-04-01
Start Page: 259
End Page: 277
Language: English
DOI: 10.1101/gad.349368.122
PUBMED: 35318270
PROVIDER: scopus
PMCID: PMC8973851
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126909507&doi=10.1101%2fgad.349368.122&partnerID=40&md5=4c346eeffe98fd208556f9d4a0362675
Notes: Review -- Export Date: 2 May 2022 -- Source: Scopus
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MSK Authors
  1. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
  2. Jan Philipp Bewersdorf
    96 Bewersdorf
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