Extracolonic findings at CT colonography in an oncological hospital setting and why they matter Journal Article
| Authors: | Ward, J. M.; Agridag Ucpinar, B.; Fernandes, M. C.; Zheng, J.; Capanu, M.; Gangai, N.; Gollub, M. J.; Horvat, N. |
| Article Title: | Extracolonic findings at CT colonography in an oncological hospital setting and why they matter |
| Abstract: | Purpose: To evaluate the frequency and clinical outcome of unknown extracolonic findings in patients with cancer who underwent CT colonography (CTC). Methods: Consecutive patients who underwent CTC from February 2000–April 2016 for any indication were retrospectively included. One radiologist blinded to clinical data determined C-RADS classification for all extracolonic findings on CTC reports as follows: E1: normal examination or anatomic variant, E2: clinically unimportant, E3: likely unimportant, incompletely characterized, and E4: potentially important. Another radiologist performed an unblinded review of medical records and determined if E4 findings were previously known or new, and classified new E4 findings as clinically important or unimportant on follow-up. Results: Of 855 patients, 686/855 (80.2%) had a normal examination or clinically unimportant extracolonic findings (E1 and E2) and 169/855 (19.8%) had E3–E4 extracolonic findings [99/855 (11.6%) patients had known E4 findings and 102/855 (11.9%) patients had new E4 findings]. On follow-up, among new E4 findings, 71/855 (8.3%) patients had clinically important findings, 66/855 (7.7%) had a malignant outcome previously unknown by the referring physician, and 5/855 (0.6%) had other complications, including bowel obstruction and cirrhosis. Regarding new oncological findings, new extracolonic primary tumors were detected in 13/855 (1.5%) patients, corresponding to 12.7% (13/102) of the new E4 findings. The proportion of new E4 findings on CTC with and without intravenous contrast was not significantly different [41/320 (12.8%) vs 61/535 (11.4%), p = 0.612]. Conclusion: Among oncological patients, detection of new significant E4 extracolonic findings at CTC occurred in 8.3% of all cases, including unknown cancers in 1.5%. © 2022 |
| Keywords: | adult; aged; major clinical study; liver cirrhosis; bone metastasis; pancreas cancer; follow up; lymph node metastasis; endometrium cancer; ovary cancer; image analysis; cancer screening; lung cancer; medical record review; retrospective study; cancer center; liver metastasis; lung metastasis; radiologist; computerized tomography; tomography; incidental findings; contrast enhancement; colon cancer; uterine cervix cancer; medical record; cancer care facilities; colon resection; iohexol; cancer of unknown primary site; intestine obstruction; kidney cancer; peritoneum metastasis; polypectomy; colon polyp; diseases; patient referral; image reconstruction; computed tomographic colonography; ct colonography; clinical examination; small intestine cancer; anatomical variation; clinical outcome; clinical data; very elderly; human; male; female; article; tertiary care center; hospital settings; anatomic variant; classifieds; colonography reporting and data system |
| Journal Title: | Clinical Imaging |
| Volume: | 86 |
| ISSN: | 0899-7071 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-06-01 |
| Start Page: | 98 |
| End Page: | 102 |
| Language: | English |
| DOI: | 10.1016/j.clinimag.2022.03.020 |
| PROVIDER: | scopus |
| PUBMED: | 35429830 |
| PMCID: | PMC9432346 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2022 -- Source: Scopus |
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