"Boom-Boom" very low dose, 2 fraction radiation therapy for the treatment of indolent non-Hodgkin lymphoma in the palliative setting Meeting Abstract
| Authors: | Adams, C.; Cho, G.; Yahalom, J. |
| Abstract Title: | "Boom-Boom" very low dose, 2 fraction radiation therapy for the treatment of indolent non-Hodgkin lymphoma in the palliative setting |
| Meeting Title: | 47th Annual Congress of the Oncology Nursing Society (ONS) |
| Abstract: | Very low dose radiation therapy (VLDRT) given as 2 Gy in 2 fractions (referred as "boom-boom" due to its quick administration) is a palliative treatment alternative to the current standard of 24 Gy for indolent non-Hodgkin lymphomas (NHL) such as follicular lymphoma and marginal zone lymphoma (MZL). VLDRT treatment has been available for more than 10 years in many academic settings. However, a review of the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Oncology Nursing Society data demonstrated no information on this type of radiation treatment option in the nursing literature. The purpose of this poster is close the gap in the nursing literature, educate oncology nurses about the rationale for the use of VLDRT for certain non-Hodgkin lymphomas (NHL), and highlight the benefits of a shorter treatment schedule and decreased radiation related toxicity for the patient. Indolent lymphomas such as FL and MZL have been long known to be extremely radiosensitive. A randomized study by Lowry et al demonstrated that a dose of 24Gy (12 Treatments), compared to historical doses of 40-45 Gy (20 treatments), proved effective for control of most cases of localized FL and this dose became the standard of care for this population. A United Kingdom randomized study called FORT then compared the use of 24 Gy vs 4 Gy for radical or palliative local control of follicular lymphoma or marginal zone lymphoma demonstrated that while 24 Gy remains the standard dose for curative treatment of localized disease, 4Gy remains an excellent alternative in the relapse and palliative setting. Preparation of the patient for treatment with VLDRT remains the same as treatment with the 24Gy. The low dose allows for retreatment to the same field as needed. The plan of treatment is developed using either a CT, a PET/CT simulation, or a clinical setup. Immobilization devices are created and used during the simulation scans and treatments to ensure stability of the field of treatment. While radiation related toxicities were low in both FORT treatment groups, the rapid treatment schedule of only 2 consecutive days vs 12 days is significant to promote improved quality of life in the palliative setting. |
| Keywords: | palliative care; radiation dosage; california; lymphoma, non-hodgkin's -- radiotherapy; congresses and conferences -- california |
| Journal Title: | Oncology Nursing Forum |
| Volume: | 49 |
| Issue: | 2 |
| Meeting Dates: | 2022 Apr 27-May 1 |
| Meeting Location: | Anaheim, CA |
| ISSN: | 0190-535X |
| Publisher: | Oncology Nursing Society (ONS) |
| Date Published: | 2022-03-01 |
| Start Page: | E6 |
| Language: | English |
| DOI: | 10.1188/22.Onf.E2 |
| PROVIDER: | EBSCOhost |
| PROVIDER: | cinahl |
| PUBMED: | 35191905 |
| DOI/URL: | |
| Notes: | Meeting abstract: P6 in PDF named "2022 ONS Congress Poster Abstracts" -- Source: Cinahl |
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