Brainstem primitive neuroectodermal tumors (bstPNET): Results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue Journal Article

  

Authors:	Fangusaro, J. R.; Jubran, R. F.; Allen, J.; Gardner, S.; Dunkel, I. J.; Rosenblum, M.; Atlas, M. P.; Gonzalez-Gomez, I.; Miller, D.; Finlay, J. L.
Article Title:	Brainstem primitive neuroectodermal tumors (bstPNET): Results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue
Abstract:	We have evaluated the response rate and survival utilizing intensified chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) and adjuvant radiation therapy in six young children with newly diagnosed brainstem primitive neuroectodermal tumors (bstPNET). Following maximum surgical resection of the turner, patients received high dose induction chemotherapy including vincristine, cisplatin, cyclophosphamide, and etoposide. Eligible patients received a single cycle of rnyeloalblative chemotherapy followed by AuHCR. Two patients survive at least 32 months with stable disease. This approach provides an alternative for young patients with bstPNET who in prior reports have had a uniformly fatal prognosis.
Keywords:	chemotherapy; children; brainstem; pons; primitive; autologous transplant; neuroectodermal tumor; intraaxial endophytic tumors; and/or medulla-oblongata
Journal Title:	Pediatric Blood and Cancer
Volume:	50
Issue:	3
ISSN:	1545-5009
Publisher:	Wiley Periodicals, Inc
Date Published:	2008-03-01
Start Page:	715
End Page:	717
Language:	English
ACCESSION:	WOS:000252587300057
DOI:	10.1002/pbc.21032
PROVIDER:	wos
PUBMED:	17009232
Notes:	--- - Article - "Source: Wos"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/19370