Roles of the core components of the mammalian miRISC in chromatin biology Journal Article


Authors: La Rocca, G.; Cavalieri, V.
Article Title: Roles of the core components of the mammalian miRISC in chromatin biology
Abstract: The Argonaute (AGO) and the Trinucleotide Repeat Containing 6 (TNRC6) family proteins are the core components of the mammalian microRNA-induced silencing complex (miRISC), the machinery that mediates microRNA function in the cytoplasm. The cytoplasmic miRISC-mediated post-transcriptional gene repression has been established as the canonical mechanism through which AGO and TNRC6 proteins operate. However, growing evidence points towards an additional mechanism through which AGO and TNRC6 regulate gene expression in the nucleus. While several mechanisms through which miRISC components function in the nucleus have been described, in this review we aim to summarize the major findings that have shed light on the role of AGO and TNRC6 in mammalian chromatin biology and on the implications these novel mechanisms may have in our understanding of regulating gene expression. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: microrna; epigenetics; chromatin; argonaute; mirisc; tnrc6
Journal Title: Genes
Volume: 13
Issue: 3
ISSN: 2073-4425
Publisher: MDPI  
Date Published: 2022-03-01
Start Page: 414
Language: English
DOI: 10.3390/genes13030414
PROVIDER: scopus
PMCID: PMC8954937
PUBMED: 35327968
DOI/URL:
Notes: Review -- Export Date: 1 April 2022 -- Source: Scopus
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