Merging data curation and machine learning to improve nanomedicines Journal Article
| Authors: | Chen, C.; Yaari, Z.; Apfelbaum, E.; Grodzinski, P.; Shamay, Y.; Heller, D. A. |
| Article Title: | Merging data curation and machine learning to improve nanomedicines |
| Abstract: | Nanomedicine design is often a trial-and-error process, and the optimization of formulations and in vivo properties requires tremendous benchwork. To expedite the nanomedicine research progress, data science is steadily gaining importance in the field of nanomedicine. Recently, efforts have explored the potential to predict nanomaterials synthesis and biological behaviors via advanced data analytics. Machine learning algorithms process large datasets to understand and predict various material properties in nanomedicine synthesis, pharmacologic parameters, and efficacy. “Big data” approaches may enable even larger advances, especially if researchers capitalize on data curation methods. However, the concomitant use of data curation processes needed to facilitate the acquisition and standardization of large, heterogeneous data sets, to support advanced data analytics methods such as machine learning has yet to be leveraged. Currently, data curation and data analytics areas of nanotechnology-focused data science, or 'nanoinformatics', have been proceeding largely independently. This review highlights the current efforts in both areas and the potential opportunities for coordination to advance the capabilities of data analytics in nanomedicine. © 2022 Elsevier B.V. |
| Keywords: | cancer chemotherapy; review; drug efficacy; antineoplastic agent; in vivo study; drug design; data base; information processing; prediction; simulation; standardization; artificial intelligence; data analysis; medical nanotechnology; in-vivo; nanomedicine; synthesis; drug delivery system; nanocarrier; nanotechnology; virtual reality; property; medical informatics; machine learning; data synthesis; data mining; biological behavior; cancer therapeutics; learning algorithms; big data; particle characterization; large dataset; data science; data analytics; excipient; data curation; nanoparticles, data mining; nanoparticle, data mining; optimisations; trial-and-error process |
| Journal Title: | Advanced Drug Delivery Reviews |
| Volume: | 183 |
| ISSN: | 0169-409X |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2022-04-01 |
| Start Page: | 114172 |
| Language: | English |
| DOI: | 10.1016/j.addr.2022.114172 |
| PUBMED: | 35189266 |
| PROVIDER: | scopus |
| PMCID: | PMC9233944 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 April 2022 -- Source: Scopus |
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