Harder, better, faster, stronger: Biochemistry and biophysics in the immunosurveillance concert Journal Article

   

Authors:	Tello-Lafoz, M.; de Jesus, M. M.; Huse, M.
Article Title:	Harder, better, faster, stronger: Biochemistry and biophysics in the immunosurveillance concert
Abstract:	Antitumor immunosurveillance is triggered by immune cell recognition of characteristic biochemical signals on the surfaces of cancer cells. Recent data suggest that the mechanical properties of cancer cells influence the strength of these signals, with physically harder target cells (more rigid) eliciting better, faster, and stronger cytotoxic responses against metastasis. Using analogies to a certain electronic music duo, we argue that the biophysical properties of cancer cells and their environment can adjust the volume and tone of the antitumor immune response. We also consider the potential influence of biomechanics-based immunosurveillance in disease progression and posit that targeting the biophysical properties of cancer cells in concert with their biochemical features could increase the efficacy of immunotherapy. © 2021 Elsevier Ltd
Journal Title:	Trends in Immunology
Volume:	43
Issue:	2
ISSN:	1471-4906
Publisher:	Elsevier Inc.
Date Published:	2022-02-01
Start Page:	96
End Page:	105
Language:	English
DOI:	10.1016/j.it.2021.12.003
PUBMED:	34973924
PROVIDER:	scopus
PMCID:	PMC8810625
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121979950&doi=10.1016%2fj.it.2021.12.003&partnerID=40&md5=63582c1972a8b0016f85f54ced0b7c98
Notes:	Review -- Export Date: 1 March 2022 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/192986