Progressive nodular histiocytosis in a 9-year-old boy treated with cobimetinib Journal Article
| Authors: | Buján, M. M.; Sánchez La Rosa, C.; Galluzzo Mutti, M. L.; Braier, J.; Diamond, E. L. |
| Article Title: | Progressive nodular histiocytosis in a 9-year-old boy treated with cobimetinib |
| Abstract: | Progressive nodular histiocytosis is a rare variant of non-Langerhans cell histiocytosis that affects the skin and mucous membranes and displays a progressive clinical course and poor response to treatment. We describe a case of severe progressive nodular histiocytosis harboring a KRAS p.G12S mutation in a 9-year-old boy, refractory to chemotherapy, who was successfully treated with the MEK inhibitor cobimetinib. This is the first report of the use of MEK inhibition for this histiocytosis subtype in a pediatric patient. © 2021 Wiley Periodicals LLC. |
| Keywords: | child; clinical article; school child; gene mutation; case report; drug efficacy; disease severity; skin disease; piperidines; histiocytosis; oncogene k ras; skin diseases; langerhans cell histiocytosis; piperidine derivative; histiocytosis, langerhans-cell; humans; human; male; article; cobimetinib; azetidine derivative; azetidines; progressive nodular histiocytosis |
| Journal Title: | Pediatric Dermatology |
| Volume: | 39 |
| Issue: | 1 |
| ISSN: | 0736-8046 |
| Publisher: | Blackwell Scientific Publications |
| Date Published: | 2022-01-01 |
| Start Page: | 115 |
| End Page: | 118 |
| Language: | English |
| DOI: | 10.1111/pde.14887 |
| PUBMED: | 34935192 |
| PROVIDER: | scopus |
| PMCID: | PMC8819602 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2022 -- Source: Scopus |
