Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women Journal Article
| Authors: | Cho, B. A.; Iyengar, N. M.; Zhou, X. K.; Mendieta, H.; Winston, L.; Falcone, D. J.; Landa, J.; Morrow, M.; Dannenberg, A. J. |
| Article Title: | Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women |
| Abstract: | Increased trunk fat is associated with an elevated risk of breast cancer in normal-weight postmenopausal women. The main objective of this study was to determine whether levels of trunk fat are associated with changes in breast gene expression in normal-weight women. Non-tumorous breast tissue was collected from 32 normal BMI women who underwent mastectomy for breast cancer risk reduction or treatment. Body composition was measured by dual-energy x-ray absorptiometry. High levels of trunk fat were associated with a large number of differentially expressed genes and changes in multiple pathways and processes potentially linked to breast cancer pathogenesis. High levels of trunk fat were also associated with an elevated immune score and increased levels of leptin, CCL2, VEGF-C, IL6, and aromatase. Collectively, these results help to explain why high levels of trunk fat are associated with an increased risk of breast cancer in normal BMI women. © 2022, The Author(s). |
| Keywords: | adult; controlled study; human tissue; protein expression; middle aged; cancer surgery; major clinical study; cancer risk; hypertension; leptin; breast cancer; gene expression; mastectomy; body weight; vasculotropin c; body mass; diabetes mellitus; interleukin 6; down regulation; dyslipidemia; body composition; premenopause; postmenopause; monocyte chemotactic protein 1; aromatase; fat; dual energy x ray absorptiometry; adipocyte; trunk; human; female; article; differential gene expression; breast tissue |
| Journal Title: | npj Breast Cancer |
| Volume: | 8 |
| ISSN: | 2374-4677 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2022-01-27 |
| Start Page: | 15 |
| Language: | English |
| DOI: | 10.1038/s41523-021-00369-8 |
| PROVIDER: | scopus |
| PMCID: | PMC8795267 |
| PUBMED: | 35087024 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2022 -- Source: Scopus |
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