Clinical outcomes with use of radiation therapy and risk of transformation in early-stage follicular lymphoma Journal Article
| Authors: | Sha, F.; Okwali, M.; Alperovich, A.; Caron, P. C.; Falchi, L.; Hamilton, A.; Hamlin, P. A.; Horwitz, S. M.; Joffe, E.; Khan, N.; Kumar, A.; Matasar, M. J.; Moskowitz, A. J.; Noy, A.; Owens, C.; Palomba, L. M.; Rodriguez-Rivera, I.; Straus, D.; von Keudell, G.; Zelenetz, A. D.; Yahalom, J.; Dogan, A.; Schöder, H.; Seshan, V. E.; Salles, G.; Younes, A.; Batlevi, C. L. |
| Article Title: | Clinical outcomes with use of radiation therapy and risk of transformation in early-stage follicular lymphoma |
| Abstract: | Between 1998 and 2009, a total of 295 patients (median age 58, 53% females) with newly diagnosed early-stage follicular lymphoma (FL) were managed at Memorial Sloan Kettering Cancer Center. Approximately half of patients (137, 46%) underwent initial observation and half (158, 54%) immediate treatment: radiation alone (n = 108), systemic treatment alone (n = 29), or combined modality treatment (n = 21). Median follow-up was 8.4 years (range 0.3–17.2), and 10-year overall survival (OS) was 87.2%. OS was similar between initially-observed and immediately-treated patients (hazard ratio [HR]: 1.25, 95% CI: 0.67–2.36, p = 0.49). For patients receiving radiation alone, 5-year OS was 98.0%. Patients selected for systemic therapy alone had high-risk baseline features and had shorter OS than patients treated with radiation alone (HR 3.38, 95% CI 1.29–8.86, p = 0.01). Combined modality treatment did not yield superior survival compared with radiation alone (P > 0.05) but was associated with better progression-free survival (HR 0.36, 95% CI 0.14–0.90, p = 0.03). The rate of transformation increased steadily over time and was 4.2% at 5 years and 10.8% at 10 years. This modern-era analysis rationalized the role of initial observation in patients with early-stage FL although patients receiving radiation therapy also demonstrate excellent outcome. © 2022, The Author(s). |
| Journal Title: | Blood Cancer Journal |
| Volume: | 12 |
| Issue: | 2 |
| ISSN: | 2044-5385 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2022-02-10 |
| Start Page: | 29 |
| Language: | English |
| DOI: | 10.1038/s41408-022-00620-w |
| PUBMED: | 35145059 |
| PROVIDER: | scopus |
| PMCID: | PMC8831497 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2022 -- Source: Scopus |
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