Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML Journal Article

   

Authors:	Menghrajani, K.; Gomez-Arteaga, A.; Madero-Marroquin, R.; Zhang, M. J.; Bo-Subait, K.; Sanchez, J.; Wang, H. L.; Aljurf, M.; Assal, A.; Bacher, V. U.; Badawy, S. M.; Bejanyan, N.; Bhatt, V. R.; Bredeson, C.; Byrne, M.; Castillo, P.; Cerny, J.; Chhabra, S.; Ciurea, S. O.; DeFilipp, Z.; Farhadfar, N.; Gadalla, S.; Gale, R. P.; Ganguly, S.; Gowda, L.; Grunwald, M. R.; Hashmi, S.; Hildebrandt, G.; Kanakry, C. G.; Kansagra, A.; Khimani, F.; Krem, M.; Lazarus, H.; Liu, H.; Martino, R.; Michelis, F. V.; Nathan, S.; Nishihori, T.; Olsson, R.; Reshef, R.; Rizzieri, D.; Rowe, J. M.; Savani, B. N.; Seo, S.; Sharma, A.; Solh, M.; Ustun, C.; Verdonck, L. F.; Hourigan, C.; Sandmaier, B.; Litzow, M.; Kebriaei, P.; Weisdorf, D.; Zhang, Y.; Tallman, M. S.; Saber, W.
Article Title:	Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML
Abstract:	Little is known about whether risk classification at diagnosis predicts post-hematopoietic cell transplantation (HCT) outcomes in patients with acute myeloid leukemia (AML). We evaluated 8709 patients with AML from the CIBMTR database, and after selection and manual curation of the cytogenetics data, 3779 patients in first complete remission were included in the final analysis: 2384 with intermediate-risk, 969 with adverse-risk, and 426 with KMT2A-rearranged disease. An adjusted multivariable analysis detected an increased risk of relapse for patients with KMT2A-rearranged or adverse-risk AML as compared to those with intermediate-risk disease (hazards ratio [HR], 1.27; P 5 .01; HR, 1.71; P , .001, respectively). Leukemia-free survival was similar for patients with KMT2A rearrangement or adverse risk (HR, 1.26; P 5 .002, and HR, 1.47; P , .001), as was overall survival (HR, 1.32; P , .001, and HR, 1.45; P , .001). No differences in outcome were detected when patients were stratified by KMT2A fusion partner. This study is the largest conducted to date on post-HCT outcomes in AML, with manually curated cytogenetics used for risk stratification. Our work demonstrates that risk classification at diagnosis remains predictive of post-HCT outcomes in AML. It also highlights the critical need to develop novel treatment strategies for patients with KMT2A-rearranged and adverse-risk disease. © 2022 American Society of Hematology. All rights reserved.
Journal Title:	Blood Advances
Volume:	6
Issue:	3
ISSN:	2473-9529
Publisher:	American Society of Hematology
Date Published:	2022-02-08
Start Page:	828
End Page:	847
Language:	English
DOI:	10.1182/bloodadvances.2021004881
PUBMED:	34551064
PROVIDER:	scopus
PMCID:	PMC8945306
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124675874&doi=10.1182%2fbloodadvances.2021004881&partnerID=40&md5=f60b2848355ad6e1cc1e090d8b62eccc
Notes:	Article -- Export Date: 1 March 2022 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/192669