Retrospective, multicenter analysis comparing conventional with oncoplastic breast conserving surgery: Oncological and surgical outcomes in women with high-risk breast cancer from the OPBC-01/iTOP2 study Journal Article
| Authors: | Fitzal, F.; Bolliger, M.; Dunkler, D.; Geroldinger, A.; Gambone, L.; Heil, J.; Riedel, F.; de Boniface, J.; Andre, C.; Matrai, Z.; Pukancsik, D.; Paulinelli, R. R.; Ostapenko, V.; Burneckis, A.; Ostapenko, A.; Ostapenko, E.; Meani, F.; Harder, Y.; Bonollo, M.; Alberti, A. S. M.; Tausch, C.; Papassotiropoulos, B.; Helfgott, R.; Heck, D.; Fehrer, H. J.; Acko, M.; Schrenk, P.; Trapp, E. K.; Gunda, P. T.; Clara, P.; Montagna, G.; Ritter, M.; Blohmer, J. U.; Steffen, S.; Romics, L.; Morrow, E.; Lorenz, K.; Fehr, M.; Weber, W. P. |
| Article Title: | Retrospective, multicenter analysis comparing conventional with oncoplastic breast conserving surgery: Oncological and surgical outcomes in women with high-risk breast cancer from the OPBC-01/iTOP2 study |
| Abstract: | Introduction: Recent data suggest that margins ≥2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tübingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tübingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tübingen 3-4). Methods: Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed. Results: A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin <1 mm: 17% vs. 6%, p < 0.001). There were significantly more re-excisions due to R1 (“ink on tumor”) in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups. Conclusions: Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI. © 2021, The Author(s). |
| Keywords: | adult; cancer survival; controlled study; treatment outcome; aged; cancer surgery; retrospective studies; major clinical study; overall survival; clinical trial; cancer recurrence; systemic therapy; cancer radiotherapy; recurrence risk; antineoplastic agent; breast cancer; biology; tumor volume; breast neoplasms; breast reconstruction; mammaplasty; retrospective study; high risk patient; multicenter study; breast tumor; partial mastectomy; reoperation; intermethod comparison; hormonal therapy; neoadjuvant chemotherapy; mastectomy, segmental; surgical margin; clinical outcome; breast-conserving surgery; local recurrence free survival; humans; human; female; article; distant recurrence free survival; distant disease free survival |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 29 |
| Issue: | 2 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2022-02-01 |
| Start Page: | 1061 |
| End Page: | 1070 |
| Language: | English |
| DOI: | 10.1245/s10434-021-10809-1 |
| PUBMED: | 34647202 |
| PROVIDER: | scopus |
| PMCID: | PMC8724061 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2022 -- Source: Scopus |
