Amyotrophic lateral sclerosis is over-represented in two Huntington’s disease brain bank cohorts: Further evidence to support genetic pleiotropy of pathogenic HTT gene expansion Journal Article
| Authors: | Hickman, R. A.; Dewan, R.; Cortes, E.; Traynor, B. J.; Marder, K.; Vonsattel, J. P. |
| Article Title: | Amyotrophic lateral sclerosis is over-represented in two Huntington’s disease brain bank cohorts: Further evidence to support genetic pleiotropy of pathogenic HTT gene expansion |
| Keywords: | adult; clinical article; human tissue; aged; middle aged; gene mutation; case report; letter; cohort analysis; depression; disease severity; nucleocytoplasmic transport; family history; motor cortex; brain stem; degenerative disease; pleiotropy; motoneuron; nerve degeneration; protein aggregation; huntington chorea; pyramidal tract; pyramidal nerve cell; cag repeat; amyotrophic lateral sclerosis; nucleus accumbens; ubiquitinated protein; caudate nucleus; human; male; female; left handedness; huntingtin; protein aggregate; sequestosome 1; guanine nucleotide exchange c9orf72; tar dna binding protein; facial nerve nucleus; hypoglossal nucleus; medial lemniscus; motoneuron nucleus; spinal cord ventral horn |
| Journal Title: | Acta Neuropathologica |
| Volume: | 143 |
| Issue: | 1 |
| ISSN: | 0001-6322 |
| Publisher: | Springer |
| Date Published: | 2022-01-01 |
| Start Page: | 105 |
| End Page: | 108 |
| Language: | English |
| DOI: | 10.1007/s00401-021-02385-1 |
| PUBMED: | 34800149 |
| PROVIDER: | scopus |
| PMCID: | PMC8918027 |
| DOI/URL: | |
| Notes: | Letter -- Export Date: 1 February 2022 -- Source: Scopus |
