Pre-diagnostic telomere length and colorectal cancer risk Journal Article

   


Authors: Yang, K.; Prescott, J.; Hazra, A.; Meyerhardt, J. A.; Zhang, X.; De Vivo, I.; Chan, A. T.; Du, M.; Giovannucci, E. L.; Nan, H.
Article Title: Pre-diagnostic telomere length and colorectal cancer risk
Abstract: Background: Progressive telomere shortening may be related to genomic instability and carcinogenesis. Prospective evidence relating telomere length (TL) with colorectal cancer (CRC) risk has been limited and inconsistent. Methods: We examined the association between pre-diagnostic peripheral blood leukocyte TL and CRC risk in two matched case-control studies nested within the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS). Relative leukocyte TL was measured using qPCR among 356 incident CRC cases and 801 controls (NHS: 186/465, HPFS: 170/336). Results: We did not find a significant association between pre-diagnostic TL and CRC risk [in all participants, multivariable-adjusted odds ratio (OR) (95% CI) for TL Quartile 1 (shortest) vs. Quartile 4 (longest) = 1.36 (0.85, 2.17), P-trend = 0.27; OR (95% CI) per 1 SD decrease in TL = 1.12 (0.92, 1.36)]. Conclusions: Our prospective analysis did not support a significant association between pre-diagnostic leukocyte TL and CRC risk. © 2022 Elsevier Ltd
Keywords: adult; controlled study; aged; major clinical study; case control study; cancer risk; follow up; polymerase chain reaction; colorectal cancer; body mass; health practitioner; blood sampling; colon cancer; alcohol; physical activity; alcohol consumption; trend study; caucasian; rectal cancer; telomere length; never smoker; nested case-control study; human; male; female; article; leukocyte telomere length; current smoker; ex-smoker; peripheral blood leukocyte
Journal Title: Cancer Epidemiology
Volume: 77
ISSN: 1877-7821
Publisher: Elsevier Inc.  
Date Published: 2022-04-01
Start Page: 102100
Language: English
DOI: 10.1016/j.canep.2022.102100
PROVIDER: scopus
PUBMED: 35033923
PMCID: PMC8923959
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122621713&doi=10.1016%2fj.canep.2022.102100&partnerID=40&md5=ba7513678e591844e7991fd5f6478171
Notes: Article -- Export Date: 1 February 2022 -- Source: Scopus
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  1. Mengmeng Du
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