Tumor response to radiopharmaceutical therapies: The knowns and the unknowns Review

  


Authors: Sgouros, G.; Dewaraja, Y. K.; Escorcia, F.; Graves, S. A.; Hope, T. A.; Iravani, A.; Pandit-Taskar, N.; Saboury, B.; James, S. S.; Zanzonico, P. B.
Review Title: Tumor response to radiopharmaceutical therapies: The knowns and the unknowns
Abstract: Radiopharmaceutical therapy (RPT) is defined as the delivery of radioactive atoms to tumor-associated targets. In RPT, imaging is built into the mode of treatment since the radionuclides used in RPT often emit photons or can be imaged using a surrogate. Such imaging may be used to estimate tumor-absorbed dose. We examine and try to elucidate those factors that impact the absorbed dose-versus-response relationship for RPT agents. These include the role of inflammation- or immune-mediated effects, the significance of theranostic imaging, radiobiology, differences in dosimetry methods, pharmacokinetic differences across patients, and the impact of tumor hypoxia on response to RPT. © 2021 by the Society of Nuclear Medicine and Molecular Imaging.
Keywords: radiopharmaceuticals; neoplasm; neoplasms; dosimetry; imaging; radiometry; theranostics; radiobiology; radionuclide therapy; humans; human; radiopharmaceutical therapy
Journal Title: Journal of Nuclear Medicine
Volume: 62
Issue: Suppl. 3
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2021-12-01
Start Page: 12S
End Page: 22S
Language: English
DOI: 10.2967/jnumed.121.262750
PUBMED: 34857617
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123137633&doi=10.2967%2fjnumed.121.262750&partnerID=40&md5=afd8a6227722b1ac246374ce2ec718f8
Notes: Article -- Export Date: 1 February 2022 -- Source: Scopus
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MSK Authors
  1. Neeta Pandit-Taskar
    344 Pandit-Taskar
  2. Pat B Zanzonico
    357 Zanzonico
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