Combination brentuximab vedotin and bendamustine for pediatric patients with relapsed/refractory Hodgkin lymphoma Journal Article
| Authors: | Forlenza, C. J.; Gulati, N.; Mauguen, A.; Absalon, M. J.; Castellino, S. M.; Franklin, A.; Keller, F. G.; Shukla, N. |
| Article Title: | Combination brentuximab vedotin and bendamustine for pediatric patients with relapsed/refractory Hodgkin lymphoma |
| Abstract: | In patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL), achieving a complete metabolic response (CMR) after salvage therapy is associated with superior outcomes, and optimal treatments must be identified. The combination of brentuximab vedotin and bendamustine (BVB), although highly active in adult patients, has not been extensively evaluated in pediatric patients with R/R HL. We performed a multicenter, retrospective review of pediatric patients <21 years of age with R/R HL treated with BVB from January 2016 through July 2019. Response was assessed by local radiologists according to Lugano classification criteria. Twenty-nine patients (17 relapsed, 12 refractory) with a median age of 16 years (range, 10-20) were treated with BVB and received a median of 3 cycles of therapy (range, 2-7). Patients received an infusion of 1.8 mg/kg of BV on day 1 with bendamustine 90 mg/m2 on days 1 and 2 of 3-week cycles. Nineteen patients (66%) achieved a CMR (95% CI, 46-82). An objective response was observed in 23 patients (objective response rate, 79%; 95% CI, 60-92). The most common grade 3 and 4 toxicities were hematologic, and 3 patients (10%) experienced grade 3 infusion reactions. Seventeen of 18 patients underwent successful mobilization and collection of stem cells. Sixteen patients (13 autologous, 3 allogeneic) received a consolidative transplant after BVB. The 3-year post-BVB event-free and overall survival were 65% (95% CI, 46-85) and 89% (95% CI, 74-100), respectively. For pediatric patients with R/R HL, BVB was well tolerated and compared favorably with currently accepted salvage regimens. ß 2021 by The American Society of Hematology. |
| Keywords: | adolescent; child; clinical article; event free survival; treatment response; overall survival; prednisone; allogeneic stem cell transplantation; salvage therapy; doxorubicin; cancer combination chemotherapy; treatment duration; cancer staging; multiple cycle treatment; etoposide; bendamustine; cyclophosphamide; vincristine; autologous stem cell transplantation; retrospective study; hodgkin disease; age; radiologist; multicenter study; drug response; stem cell mobilization; bleomycin; cancer classification; gender; drug tolerance; brentuximab vedotin; human; male; female; article; pediatric patient; complete metabolic response; lugano classification |
| Journal Title: | Blood Advances |
| Volume: | 5 |
| Issue: | 24 |
| ISSN: | 2473-9529 |
| Publisher: | American Society of Hematology |
| Date Published: | 2021-12-28 |
| Start Page: | 5519 |
| End Page: | 5524 |
| Language: | English |
| DOI: | 10.1182/bloodadvances.2021005268 |
| PUBMED: | 34559223 |
| PROVIDER: | scopus |
| PMCID: | PMC8714712 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2022 -- Source: Scopus |
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