Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill Editorial

  


Authors: Uhlitz, F.; Zamarin, D.
Title: Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill
Abstract: High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)(+) tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.
Journal Title: Cancer Cell
Volume: 39
Issue: 12
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2021-12-13
Start Page: 1567
End Page: 1569
Language: English
ACCESSION: WOS:000731472200007
DOI: 10.1016/j.ccell.2021.10.011
PROVIDER: wos
PUBMED: 34739843
Notes: Editorial Material -- Source: Wos
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MSK Authors
  1. Dmitriy Zamarin
    201 Zamarin
  2. Florian Soeren Uhlitz
    6 Uhlitz
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