Can molecular insights guide treatment of AML evolved from MPNs? Review
| Authors: | Crispino, J.; Rampal, R. |
| Review Title: | Can molecular insights guide treatment of AML evolved from MPNs? |
| Abstract: | Leukemic transformation of myeloproliferative neoplasms (MPNs) is associated with dismal outcomes. The genetic complexity of leukemic transformation of MPNs is being deciphered and will likely result in targeted therapy approaches. Ongoing trials are investigating the efficacy of emerging treatments for this high-risk patient population. This review has outlined recent progress in the understanding and treatment of leukemia arising from MPNs. |
| Keywords: | overall survival; primary myelofibrosis; neoplasms; transplantation; thrombocythemia; transformation; mutations; phase; cr; acute myeloid-leukemia; clinical-significance; acute; genetic-analysis; aml; myeloid leukemia; myeloproliferative; complete remission; tp53; myeloproliferative neoplasms; essential; prognosis; allo-hsct; allogeneic hematopoietic stem cell; os; stk11; mpns; serine threonine kinase 11 |
| Journal Title: | Best Practice and Research: Clinical Haematology |
| Volume: | 34 |
| Issue: | 4 |
| ISSN: | 1521-6926 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-12-01 |
| Start Page: | 101323 |
| Language: | English |
| ACCESSION: | WOS:000727210100017 |
| DOI: | 10.1016/j.beha.2021.101323 |
| PROVIDER: | wos |
| PUBMED: | 34865695 |
| Notes: | Article -- Source: Wos |
