Relationship between cognitive functioning and frailty in older breast cancer survivors Journal Article
| Authors: | Ahles, T. A.; Schofield, E.; Li, Y.; Ryan, E.; Root, J. C.; Patel, S. K.; McNeal, K.; Gaynor, A.; Tan, H.; Katheria, V.; Vazquez, J.; Traina, T.; Hurria, A. |
| Article Title: | Relationship between cognitive functioning and frailty in older breast cancer survivors |
| Abstract: | Introduction: The relationship between cognitive function and frailty in older, long-term breast cancer survivors was examined. Materials and methods: Breast cancer survivors who were diagnosed and treated at 60 years of age or above and were 5–15 year disease-free survivors and non-cancer controls matched on age and education were evaluated with neuropsychological tests and the Comprehensive Geriatric Assessment which was used to assess frailty based on a deficit accumulation frailty index (DAFI). Results: Unadjusted regression analyses revealed that cancer survivors scored significantly lower on the Language (P = 0.015), Attention, Processing Speed, Executive Function (APE) (P = 0.015), and Learning and Memory (LM) (P = 0.023) domains compared to controls. However, only the LM domain remained significantly different (P = 0.002) in the adjusted analysis. Survivors had significantly higher DAFI scores compared to controls (p = 0.006) and significantly more survivors were categorized as pre-frail or frail (35%) compared to controls (23%, P = 0.009). Increasing frailty scores were associated with worse cognitive performance across all domains (all Ps ≤ 0.004). For the LM domain, there was a significant interaction (P = 0.019) between DAFI score and survivorship vs control status. Survivors demonstrated a significant linear decline in LM scores as DAFI scores increased, whereas controls demonstrated comparable scores between the robust and pre-frail DAFI groups, demonstrating decline in the frailty group only. Conclusion: Older, long-term breast cancer survivors had lower cognitive performance and higher levels of frailty compared to controls. For the Learning and Memory domain, the decline in performance began in the pre-frail range for survivors, but not controls. © 2021 Elsevier Ltd |
| Keywords: | cognition frailty; older breast cancer survivor |
| Journal Title: | Journal of Geriatric Oncology |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 1879-4068 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-01-01 |
| Start Page: | 27 |
| End Page: | 32 |
| Language: | English |
| DOI: | 10.1016/j.jgo.2021.07.011 |
| PUBMED: | 34366276 |
| PROVIDER: | scopus |
| PMCID: | PMC9262141 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2022 -- Source: Scopus |
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