Outcomes of ureteroneocystostomy in patients with cancer Journal Article
| Authors: | Stearns, G. L.; Tin, A. L.; Benfante, N. E.; Sjoberg, D. D.; Sandhu, J. S. |
| Article Title: | Outcomes of ureteroneocystostomy in patients with cancer |
| Abstract: | Objective: To determine the durability of ureteroneocystostomy as well as pre- or post-operative factors that may be associated with failure to provide appropriate renal drainage. Methods: A total of 290 patients who underwent ureteral reimplantation to native bladder between 2003 and 2015 were identified. After excluding pediatric patients and those without any follow-up, 255 patients, 3 of whom had a subsequent contralateral reimplantation were included, for 258 observations. Kaplan-Meier method and univariate Cox models were used to assess whether factors such as radiation, prior abdominal surgery, age at re-implantation, gender and BMI are associated with re-implantation failure. Results: Among 258 observations, there were 27 failures. Median follow-up time was 1.1 years from re-implantation surgery among patients without a failure.1 and 5-year ureteral re-implantation failure is 7% (95% CI 4%, 12%) and 22% (95% CI 15%, 33%), respectively. On univariate analysis, post-operative radiation was found to be strongly associated with poorer ureteral re-implantation survival (HR: 6.62; CI 2.40, 18.29; P =.0003) No significant association between re-implantation failure-free survival and age at reimplantation, gender, BMI, previous abdominal surgery, preoperative radiation and adjuvant radiation was noted (all P >.4). Conclusions: Ureteroneocystotomy in the malignant setting has reasonable success rates through five years. No preoperative factors were associated with re-implantation failure. While all patients need to be followed due to increasing rates of failure with time, patients receiving palliative or salvage radiation therapy appear to be more prone to failure requiring further intervention. © 2021 Elsevier Inc. |
| Keywords: | adult; controlled study; treatment outcome; aged; survival rate; major clinical study; postoperative period; cancer radiotherapy; follow up; cohort analysis; risk factor; risk assessment; body mass; kidney function; reoperation; clinical effectiveness; abdominal surgery; preoperative radiotherapy; failure free survival; human; male; female; article; malignant neoplasm; renal drainage; ureteroneocystostomy |
| Journal Title: | Urology |
| Volume: | 158 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2021-12-01 |
| Start Page: | 131 |
| End Page: | 134 |
| Language: | English |
| DOI: | 10.1016/j.urology.2021.08.032 |
| PUBMED: | 34499968 |
| PROVIDER: | scopus |
| PMCID: | PMC9552518 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2022 -- Source: Scopus |
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