Histologic evaluation of host immune microenvironment and its prognostic significance in oral tongue squamous cell carcinoma: A comparative study on lymphocytic host response (LHR) and tumor infiltrating lymphocytes (TILs) Journal Article

   

Authors:	Xu, B.; Salama, A. M.; Valero, C.; Yuan, A.; Khimraj, A.; Saliba, M.; Zanoni, D. K.; Ganly, I.; Ghossein, R.; Patel, S. G.; Katabi, N.
Article Title:	Histologic evaluation of host immune microenvironment and its prognostic significance in oral tongue squamous cell carcinoma: A comparative study on lymphocytic host response (LHR) and tumor infiltrating lymphocytes (TILs)
Abstract:	Background: Host immune microenvironment is a key component of anti-tumoral immune response, influencing tumor progression, regression, and treatment responses. There is a need for simple and reliable histologic measurements of host immune response in routine histopathologic diagnosis. Methods: The prognostic value of lymphocytic host response (LHR), a qualitative histologic grading scheme, was compared to stromal/intratumoral TIL (sTIL/iTIL) percentage, a quantitative measurement in a retrospective study of 329 patients with oral tongue squamous cell carcinoma (OTSCC) of 4 cm or less in size. Results: High sTIL predicted improved distant recurrence free survival on univariate survival analysis and was an independent prognostic factor for better overall survival on multivariate analysis. LHR and iTIL were not associated with the risk of nodal metastasis or outcome. Conclusions: sTIL appears to be a superior quantitative histologic measurement for the host immune microenvironment compared with the qualitative LHR grading scheme. sTIL is an independent prognostic factor for overall survival in OTSCC. © 2021 Elsevier GmbH
Keywords:	adult; aged; human cell; major clinical study; overall survival; histopathology; comparative study; tumor associated leukocyte; cohort analysis; immune response; tongue carcinoma; tumor microenvironment; mouth squamous cell carcinoma; tumor infiltrating lymphocytes; cancer prognosis; prognosis; human; male; female; article; distant recurrence free survival; oral tongue squamous cell carcinoma; lymphocytic host response
Journal Title:	Pathology Research and Practice
Volume:	228
ISSN:	0344-0338
Publisher:	Elsevier Inc.
Date Published:	2021-12-01
Start Page:	153473
Language:	English
DOI:	10.1016/j.prp.2021.153473
PUBMED:	34059347
PROVIDER:	scopus
PMCID:	PMC9423079
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107029638&doi=10.1016%2fj.prp.2021.153473&partnerID=40&md5=328ad97a930b0d5ba5cc43ae4fbfcf5d
Notes:	Article -- Export Date: 3 January 2022 -- Source: Scopus

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