Synapse - Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights Journal Article

Authors:	Alatise, O. I.; Knapp, G. C.; Sharma, A.; Chatila, W. K.; Arowolo, O. A.; Olasehinde, O.; Famurewa, O. C.; Omisore, A. D.; Komolafe, A. O.; Olaofe, O. O.; Katung, A. I.; Ibikunle, D. E.; Egberongbe, A. A.; Olatoke, S. A.; Agodirin, S. O.; Adesiyun, O. A.; Adeyeye, A.; Kolawole, O. A.; Olakanmi, A. O.; Arora, K.; Constable, J.; Shah, R.; Basunia, A.; Sylvester, B.; Wu, C.; Weiser, M. R.; Seier, K.; Gonen, M.; Stadler, Z. K.; Kemel, Y.; Vakiani, E.; Berger, M. F.; Chan, T. A.; Solit, D. B.; Shia, J.; Sanchez-Vega, F.; Schultz, N.; Brennan, M.; Smith, J. J.; Kingham, T. P.
Article Title:	Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights
Abstract:	Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa. © 2021, The Author(s).
Keywords:	biology; molecular analysis; disease treatment; nigeria; disease prevalence; cancer; biological method
Journal Title:	Nature Communications
Volume:	12
ISSN:	2041-1723
Publisher:	Nature Publishing Group
Date Published:	2021-11-24
Start Page:	6821
Language:	English
DOI:	10.1038/s41467-021-27106-w
PROVIDER:	scopus
PMCID:	PMC8613248
PUBMED:	34819518
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119827712&doi=10.1038%2fs41467-021-27106-w&partnerID=40&md5=00ef4abc77d63655f871c32db1e5acb3
Notes:	Article -- Export Date: 3 January 2022 -- Source: Scopus