Clinical activity of ripretinib in patients with advanced gastrointestinal stromal tumor harboring heterogeneous KIT/PDGFRA mutations in the phase III INVICTUS study Journal Article
| Authors: | Bauer, S.; Heinrich, M. C.; George, S.; Zalcberg, J. R.; Serrano, C.; Gelderblom, H.; Jones, R. L.; Attia, S.; D'Amato, G.; Chi, P.; Reichardt, P.; Meade, J.; Su, Y.; Ruiz-Soto, R.; Blay, J. Y.; von Mehren, M.; Schöffski, P. |
| Article Title: | Clinical activity of ripretinib in patients with advanced gastrointestinal stromal tumor harboring heterogeneous KIT/PDGFRA mutations in the phase III INVICTUS study |
| Abstract: | Most patients with gastrointestinal stromal tumor (GIST) have activating mutations in KIT/PDGFRA and are initially responsive to tyrosine kinase inhibitors (TKI). The acquisition of secondary mutations leads to refractory/relapsed disease. This study reports the results of an analysis from the phase III INVICTUS study (NCT03353753) characterizing the genomic heterogeneity of tumors from patients with advanced GIST and evaluating ripretinib efficacy across KIT/PDGFRA mutation subgroups. © 2021 American Association for Cancer Research Inc.. All rights reserved. |
| Keywords: | adult; controlled study; treatment outcome; survival rate; gene mutation; major clinical study; exon; dose response; drug efficacy; gene; gastrointestinal stromal tumor; progression free survival; randomized controlled trial; genetic association; drug effect; multicenter study; clinical effectiveness; phase 3 clinical trial; double blind procedure; genetic heterogeneity; kit gene; pdgfra gene; high throughput sequencing; human; article; circulating tumor dna; liquid biopsy; ripretinib |
| Journal Title: | Clinical Cancer Research |
| Volume: | 27 |
| Issue: | 23 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2021-12-01 |
| Start Page: | 6333 |
| End Page: | 6342 |
| Language: | English |
| DOI: | 10.1158/1078-0432.Ccr-21-1864 |
| PUBMED: | 34503977 |
| PROVIDER: | scopus |
| PMCID: | PMC9401492 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2022 -- Source: Scopus |
