Type of recurrence is associated with disease-free survival after salvage surgery for locally recurrent rectal cancer Journal Article
| Authors: | Jimenez-Rodriguez, R. M.; Yuval, J. B.; Sauve, C. E. G.; Wasserman, I.; Aggarwal, P.; Romesser, P. B.; Crane, C. H.; Yaeger, R.; Cercek, A.; Guillem, J. G.; Weiser, M. R.; Wei, I. H.; Widmar, M.; Nash, G. M.; Pappou, E. P.; Garcia-Aguilar, J.; Gollub, M. J.; Paty, P. B.; Smith, J. J. |
| Article Title: | Type of recurrence is associated with disease-free survival after salvage surgery for locally recurrent rectal cancer |
| Abstract: | Purpose: To compare the characteristics and outcomes of rectal cancer patients with local recurrence at a perianastomotic site (PA), a surgical field (SF) site, or in lateral lymph nodes (LLN). Methods: A total of 114 consecutive patients who underwent surgery for recurrent, non-metastatic rectal cancer at a single comprehensive cancer center between 1997 and 2012 were grouped on the basis of radiographic assessment of type of recurrence: PA, 76 (67%) patients; SF, 25 (22%) patients; LLN, 13 (11%) patients. Demographic, clinical, and pathological features were compared between the three groups, as were disease-free survival (DFS) and overall survival (OS). Results: Recurrence type was associated with positive circumferential margin in the primary resection (PA, 4 [6%]; SF, 4 [19%]; LLN, 3 [25%]; P = 0.027), prior neoadjuvant therapy for the primary tumor (PA, 57 [75%]; SF, 18 [72%]; LLN, 4 [31%]; P = 0.007), and location of the primary tumor in the upper rectum (PA, 33 [45%]; SF, 5 [23%]; LLN, 1 [8%]; P < 0.001). Patients with PA had longer median DFS (PA, 5.1 years; SF, 1.5 years; LLN, 1.2 years; P = 0.036). There was a non-significant trend toward longer OS and higher rates of R0 resection for PA. Conclusion: Type of recurrence after salvage surgery for locally recurrent rectal cancer is associated with longer DFS in patients with PA recurrence. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
| Keywords: | survival; recurrence; rectal cancer; salvage surgery |
| Journal Title: | International Journal of Colorectal Disease |
| Volume: | 36 |
| Issue: | 12 |
| ISSN: | 0179-1958 |
| Publisher: | Springer |
| Date Published: | 2021-12-01 |
| Start Page: | 2603 |
| End Page: | 2611 |
| Language: | English |
| DOI: | 10.1007/s00384-021-03998-4 |
| PUBMED: | 34296325 |
| PROVIDER: | scopus |
| PMCID: | PMC8923354 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2021 -- Source: Scopus |
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