A picture is worth a thousand words: A history of diagnostic imaging for lymphoma Review


Authors: Wijetunga, N. A.; Imber, B. S.; Caravelli, J. F.; Mikhaeel, N. G.; Yahalom, J.
Review Title: A picture is worth a thousand words: A history of diagnostic imaging for lymphoma
Abstract: The journey from early drawings of Thomas Hodgkin’s patients to deep learning with radiomics in lymphoma has taken nearly 200 years, and in many ways, it parallels the journey of medicine. By tracing the history of imaging in clinical lymphoma practice, we can better understand the motivations for current imaging practices. The earliest imaging modalities of the 2D era each had varied, site-dependent sensitivity, and the improved accuracy of imaging studies allowed new diagnostic and therapeutic techniques. First, we review the initial imaging technologies that were applied to understand lymphoma spread and achieve practical guidance for the earliest lymphoma treatments. Next, in the 3D era, we describe how anatomical imaging advances replaced and complemented conventional modalities. Afterward, we discuss how the PET era scans were used to understand response of tumors to treatment and risk stratification. Finally, we discuss the emergence of radiomics as a promising area of research in personalized medicine. We are now able to identify involved lymph nodes and body sites both before and after treatment to offer patients improved treatment outcomes. As imaging methods continue to improve sensitivity, we will be able to use personalized medicine approaches to give targeted and highly focused therapies at even earlier time points, and ideally, we can obtain long-term disease control and cures for lymphomas. © 2021 The Authors.
Journal Title: British Journal of Radiology
Volume: 94
Issue: 1127
ISSN: 0007-1285
Publisher: British Institute of Radiology  
Date Published: 2021-11-01
Start Page: 20210285
Language: English
DOI: 10.1259/bjr.20210285
PROVIDER: scopus
PMCID: PMC8553205
PUBMED: 34111961
DOI/URL:
Notes: Article -- Export Date: 1 December 2021 -- Source: Scopus
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MSK Authors
  1. Joachim Yahalom
    625 Yahalom
  2. Brandon Stuart Imber
    214 Imber
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