Genomic heterogeneity of AIDS retroviral isolates from North America and Zaire Journal Article
| Authors: | Benn, S.; Rutledge, R.; Folks, T.; Gold, J.; Baker, L.; McCormick, J.; Feorino, P.; Piot, P.; Quinn, T.; Martin, M. |
| Article Title: | Genomic heterogeneity of AIDS retroviral isolates from North America and Zaire |
| Abstract: | In an analysis of the genomic variation of AIDS retroviral isolates from patients living in New York, Alabama, and Zaire, restriction maps were constructed by using seven enzymes, each known to cleave the proviral DNA more than once, in conjunction with Southern blot analysis. The maps of LAV, HTLV-III, and ARV-2 as deduced from their published nucleotide sequences were included in this analysis. The results demonstrated that (i) several "signature" restriction sites were common to all isolates; (ii) with the exception of LAV and HTLV-III, the North American and European isolates were all different from one another and showed no geographical specificity; (iii) the African isolates as a group were more diverse than those from North America and Europe; and (iv) the genomic variability was concentrated within the env gene. |
| Keywords: | heredity; variance; lymphatic system; cloning, molecular; base sequence; virus antigen; dna, viral; human immunodeficiency virus; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; epidemiology; virus; virus genome; north america; human immunodeficiency virus 1; gene structure; chromosome mapping; viral proteins; southern blotting; geographic distribution; genes, viral; virus vaccine; humans; human; priority journal; dna restriction enzymes; human immunodeficiency virus 2; htlv; democratic republic of the congo; deltaretrovirus; democratic republic congo |
| Journal Title: | Science |
| Volume: | 230 |
| Issue: | 4728 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 1985-11-22 |
| Start Page: | 949 |
| End Page: | 951 |
| Language: | English |
| DOI: | 10.1126/science.2997922 |
| PROVIDER: | scopus |
| PUBMED: | 2997922 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
