Mouse monoclonal IgG3 antibody detecting G(D3) ganglioside: A phase I trial in patients with malignant melanoma Journal Article

   


Authors: Houghton, A. N.; Mintzer, D.; Cordon-Cardo, C.; Welt, S.; Fliegel, B.; Vadhan, S.; Carswell, E.; Melamed, M. R.; Oettgen, H. F.; Old, L. J.
Article Title: Mouse monoclonal IgG3 antibody detecting G(D3) ganglioside: A phase I trial in patients with malignant melanoma
Abstract: R24 is an IgG3 mouse monoclonal antibody that identifies G(D3), a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin. Twelve patients with metastatic melanoma were treated with R24 at three dose levels, 8, 80 or 240 mg/m2, over a period of 2 weeks. Peak antibody levels in the serum were dose related and ranged from <0.1 to 62 μg/ml. Inflammatory reactions (urticaria, pruritus, erythema, subcutaneous ecchymoses) were observed around tumor sites in patients treated at doses ≥ 80 mg/m2. Tumor biopsies during and after treatment showed lymphocyte and mast cell infiltration, mast cell degranulation, and complement deposition. Side effects were mild and were readily controlled by antihistamines. Major tumor regression has been observed in three patients.
Keywords: adult; clinical article; aged; middle aged; mouse; melanoma; metastasis; immunoglobulin; monoclonal antibody; antibodies, monoclonal; immunotherapy; antigens, neoplasm; immunoglobulin g; adverse drug reaction; therapy; clinical trials; antigens, surface; gangliosides; ganglioside; complement activation; humans; human; male; female; priority journal
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 82
Issue: 4
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 1985-02-01
Start Page: 1242
End Page: 1246
Language: English
DOI: 10.1073/pnas.82.4.1242
PROVIDER: scopus
PMCID: PMC397231
PUBMED: 3883355
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0343670252&doi=10.1073%2fpnas.82.4.1242&partnerID=40&md5=2129fd30c296183a3c834fe8907526b6
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Herbert F Oettgen
    130 Oettgen
  3. Alan N Houghton
    364 Houghton
  4. Lloyd J Old
    593 Old
  5. Sydney Welt
    98 Welt
  6. Myron Melamed
    148 Melamed
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