Characterization of the opioid receptor binding and animal pharmacology of meptazinol Journal Article
| Authors: | Pasternak, G. W.; Adler, B. A.; Rodriguez, J. |
| Article Title: | Characterization of the opioid receptor binding and animal pharmacology of meptazinol |
| Abstract: | Meptazinol is a unique opioid analgesic. Binding studies suggest a relatve selectivity for μ1 sites, as opposed to the other opioid receptor binding sites. This binding selectivity is consistent with meptazinol's supraspinal site of action and its sensitivity to the μ1-selective opiate antagonist naloxonazine. Furthermore, at equianalgesic doses, morphine depressed respiration to a greater degree than meptazinol. |
| Keywords: | nonhuman; animal; mice; central nervous system; drug receptor binding; brain; dogs; short survey; rats; drug monitoring; morphine; analgesia; drug binding; pharmacokinetics; naloxone; opiate receptor; n allylnormetazocine; pentazocine; buprenorphine; nalbuphine; ethylketazocine; azepines; narcotics; butorphanol; receptors, opioid; priority journal; meptazinol; enkephalin[2 alanine 5 leucine]; metenkephalin[alanine] |
| Journal Title: | Postgraduate Medical Journal |
| Volume: | 61 |
| Issue: | Suppl. 2 |
| ISSN: | 0032-5473 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 1985-01-01 |
| Start Page: | 5 |
| End Page: | 12 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 3001685 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
