Inosine analogs as anti-Leishmanial agents Journal Article
| Authors: | Rainey, P.; Nolan, P. A.; Townsend, L. B.; Robins, R. K.; Fox, J. J.; Secrist, J. A. 3rd; Santi, D. V. |
| Article Title: | Inosine analogs as anti-Leishmanial agents |
| Abstract: | Several criteria were used to select a number of inosine analogs as potential growth inhibitors of the protozoan parasite Leishmania tropica. Of nine compounds tested, seven showed a high degree of selective toxicity towards L. tropica promastigotes as compared to mouse L1210 cells; these include analogs of formycin B, 7-substituted analogs of 7-deazainosine and analogs of inosine in which the sugar moiety has been modified to confer metabolic stability. The metabolism of 7-deazainosine in L. tropica promastigotes was shown to involve conversion to cytotoxic adenosine nucleotide analogs (tubercidin derivatives) that become incorporated into RNA. The results suggest several new classes of compounds which have potential as anti-leishmanial agents. © 1985, Plenum Publishing Corporation. All rights reserved. |
| Keywords: | drug efficacy; nonhuman; mouse; in vitro study; drug screening; drug toxicity; drug metabolism; high performance liquid chromatography; drug cytotoxicity; radioisotope; protozoon; drug identification; intoxication; drug comparison; leukemia l 1210; blood and hemopoietic system; drug analysis; formycin b; 1 methylformycin b; 2 methylformycin b; 2' fluorohypoxanthine arabinoside; 7 bromo 7 deazainosine; 7 carboxamido 7 deazainosine; 7 cyano 7 deazainosine; 7 deazainosine 5' phosphate; 7 deazainosine h 3; 7 selenoformycin b; 7 thioformycin b; carbocyclic inosine; leishmania tropica; tubercidin 5' diphosphate; tubercidin 5' triphosphate; tubercidin phosphate |
| Journal Title: | Pharmaceutical Research |
| Volume: | 2 |
| Issue: | 5 |
| ISSN: | 0724-8741 |
| Publisher: | Springer Science + Business Media, LLC |
| Date Published: | 1985-09-01 |
| Start Page: | 217 |
| End Page: | 220 |
| Language: | English |
| DOI: | 10.1023/a:1016360710842 |
| PROVIDER: | scopus |
| PUBMED: | 24272839 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
