Use of the Ommaya reservoir in the prevention and treatment of CNS leukemia - An update Journal Article
| Authors: | Steinherz, P. G.; Galicich, J. H. |
| Article Title: | Use of the Ommaya reservoir in the prevention and treatment of CNS leukemia - An update |
| Abstract: | The prophylaxis of the CNS in ALL with intraventricular methotrexate therapy via an Ommaya reservoir in 18 patients resulted in a reduction of the CNS relapse rate to 11% with a 6-10+ year follow-up. This procedure proved to be safe and effective in our hands, but with newer, equally effective and less invasive methods of CNS prophylaxis now available, its use is no longer indicated. Intraventricular therapy via the Ommaya reservoir was also evaluated for its role in improving CNS remission duration after a leukemic recurrence in the CSF. The treatment of CNS relapse with intraventricular chemotherapy and low dose (600r) neuraxis radiation is encouraging. Of the ten patients treated for CNS leukemia, three are long-term (8-11+ years) survivors. Isolated CNS relapse occurred in three. The median CNS disease-free survival and the median relapse-free survival are 39 months and 21 months respectively. © 1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | child; clinical article; cancer combination chemotherapy; methotrexate; cancer therapy; acute lymphoblastic leukemia; childhood cancer; central nervous system; acute leukemia; recurrent disease; drug therapy; therapy; drug delivery system; prevention; human; ommaya reservoir; brain leukemia; central nervous system leukemia; blood and hemopoietic system; cerebrospinal fluid reservoir; meningeat leukemia |
| Journal Title: | Pediatric Hematology and Oncology |
| Volume: | 2 |
| ISSN: | 0888-0018 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 1985-01-01 |
| Start Page: | 87 |
| End Page: | 92 |
| Language: | English |
| DOI: | 10.3109/08880018509141212 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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