Abstract: |
Zinc is an important trace metal in many enzyme systems, and zinc deficiency is thought by some to play an important role in septic complications in burn patients. A number of authors have reported normal or low levels of serum or plasma zinc and/or increased urinary zinc excretion in burn patients (1-3). Although zinc supplementation has been recommended (2) there is disagreement concerning the benefits observed (3). Details with regard to nutritional support in the patients are generally lacking. Controlled studies in which normal subjects received similar nutritional support to that administered to the patients have not been reported. In the present study groups, control subjects and burn patients have been maintained on either I.V. dextrose-eletrolytes ([-]TPN) or total parenteral nutrition (TPN) for a 10-day period. Serum zinc, urinary excretion of zinc and neutrophil chemotaxis have been measured. Neutrophil chemotaxis has been correlated with the serum zinc, measured concommitantly. |